ZFIN ID: ZDB-IMAGE-120329-36
Figures for Zhu et al., 2012

Figure Caption/Comments:

Fig. 8

ALK Inhibits a Developmentally-Timed Apoptotic Response Triggered by MYCN Overexpression in the Interrenal Gland (A) Numbers of Hu+ interrenal gland cells in the DβH, ALK, MYCN, and MYCN;ALK fish at 5.5 wpf. Means of Hu+ cell numbers were compared by the two-tailed Wilcoxon signed-rank test. (B) Numbers of apoptotic Hu+ interrenal gland cells in the DβH, ALK, MYCN, and MYCN;ALK fish at 5.5 wpf. The numbers of transgenic fish at 5.5 wpf with apoptotic Hu+ cells in the interrenal gland were compared by two-tailed Fisher exact test. (C) Sagittal sections through the interrenal gland in MYCN (top panels) and MYCN;ALK (bottom panels) transgenic fish at 5.5 wpf (dorsal up, anterior left). Hu, green; activated Caspase-3, red. Hu+, activated Caspase-3+ apoptotic cells were detected in the MYCN transgenic fish (arrowheads). Dotted lines indicate the head kidney (HK) boundary. Scale bars represent 10 μm. See also Figure S7.

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