FIGURE

Fig. 1

ID
ZDB-FIG-110915-9
Publication
Zygmunt et al., 2011 - Semaphorin-PlexinD1 Signaling Limits Angiogenic Potential via the VEGF Decoy Receptor sFlt1
Other Figures
All Figure Page
Back to All Figure Page
Fig. 1

Sema-PlxnD1 Signaling Is Cell Autonomously Required within the Endothelium for Proper SeA Sprout Abundance and Distribution

(A and B) 23 hpf vasculatures, green. SBs, red. Horizontal myoseptum (HM), white dotted line. SeA sprouts, numbered. (A) WT. (B) obd.

(C and D) SeA sprout position (C) and abundance (D) in 23 hpf WT and obd. n = 8 WT, 12 obd. Error bars represent SEM. ***p < 0.001.

(E and F) WISH, 28 hpf trunks. Ectopic SeA sprouts, white arrowheads. Riboprobes: flt4 (blue), cdh5 (red). WT (E). obd (F). n = 10/10 WT, 10/10 obd.

(G and H) 32 hpf chimeric vasculatures with ECs of donor (green) and host (red) origin. Examples of ectopic SeA sprouts, white arrowheads.

(A, B, E–H) Anterior, left; dorsal, up. Scale bars represent 30 μm. See Figure S1.

Expression Data
Genes:
Fish:
Anatomical Terms:
Stage Range: 26+ somites to Prim-5

Expression Detail
Antibody Labeling
Phenotype Data
Fish:
Observed In:
Stage: 26+ somites

Phenotype Detail
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Developmental Cell, 21(2), Zygmunt, T., Gay, C.M., Blondelle, J., Singh, M.K., Flaherty, K.M., Means, P.C., Herwig, L., Krudewig, A., Belting, H.G., Affolter, M., Epstein, J.A., and Torres-Vazquez, J., Semaphorin-PlexinD1 Signaling Limits Angiogenic Potential via the VEGF Decoy Receptor sFlt1, 301-314, Copyright (2011) with permission from Elsevier. Full text @ Dev. Cell