Gene
cdh5
- ID
- ZDB-GENE-040816-1
- Name
- cadherin 5
- Symbol
- cdh5 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Is predicted to enable cadherin binding activity and calcium ion binding activity. Involved in several processes, including calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell-cell junction organization; and regulation of establishment of cell polarity. Acts upstream of or within with a positive effect on cell-cell junction organization. Acts upstream of or within circulatory system development; negative regulation of angiogenesis; and unidimensional cell growth. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be part of catenin complex. Is expressed in several structures, including angioblastic mesenchymal cell; cardiovascular system; intermediate cell mass of mesoderm; mesoderm; and nervous system. Orthologous to human CDH5 (cadherin 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 120 figures from 87 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 28 figures from 14 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR020894 | Cadherin conserved site |
| Domain | IPR000233 | Cadherin, cytoplasmic domain |
| Domain | IPR002126 | Cadherin-like |
| Family | IPR030052 | VE-cadherin |
| Family | IPR039808 | Cadherin |
| Homologous_superfamily | IPR015919 | Cadherin-like superfamily |
| Homologous_superfamily | IPR027397 | Catenin binding domain superfamily |
Domain Details Per Protein
| Protein | Length | Cadherin | Cadherin conserved site | Cadherin, cytoplasmic domain | Cadherin-like | Cadherin-like superfamily | Catenin binding domain superfamily | VE-cadherin |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F1R2I9
|
767 | |||||||
|
UniProtKB:Q68SP4
|
767 | |||||||
|
UniProtKB:B3DJF6
|
767 |
Interactions and Pathways
No data available
Plasmids