Gene

cdh5

ID
ZDB-GENE-040816-1
Name
cadherin 5
Symbol
cdh5 Nomenclature History
Previous Names
  • cadherin 5, type 2, VE-cadherin (vascular epithelium)
  • fc88a07
  • mlb
  • vascular endothelial cadherin (1)
  • vecdn (1)
  • wu:fc88a07 (1)
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to have cadherin binding activity; calcium ion binding activity; and cytoskeletal protein binding activity. Involved in circulatory system development; negative regulation of angiogenesis; and unidimensional cell growth. Predicted to localize to adherens junction; catenin complex; and cell surface. Is expressed in several structures, including angioblastic mesenchymal cell; cardiovascular system; intermediate cell mass of mesoderm; lateral mesoderm; and nervous system. Orthologous to human CDH5 (cadherin 5).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
129 figures from 95 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
28 figures from 14 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cdh5 Human Ortholog
No data available
Associated With cdh5 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR020894 Cadherin conserved site
Domain IPR000233 Cadherin, Y-type LIR-motif
Domain IPR002126 Cadherin-like
Family IPR039808 Cadherin
Homologous_superfamily IPR015919 Cadherin-like superfamily
Homologous_superfamily IPR027397 Catenin binding domain superfamily
Domain Details Per Protein
Protein Length Cadherin Cadherin conserved site Cadherin-like Cadherin-like superfamily Cadherin, Y-type LIR-motif Catenin binding domain superfamily
UniProtKB:Q68SP4 767
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-cdh5 Rabbit
  • IHC
  • WB
29
Ab2-cdh5 polyclonal Rabbit
  • WB
SDIX
1
Ab6-cdh5 polyclonal Rat
  • IHC
1
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations