FIGURE

Fig. 2

ID

ZDB-FIG-100603-27

Publication

Piloto et al., 2010 - Ovo1 links Wnt signaling with N-cadherin localization during neural crest migration

Other Figures

All Figure Page

Back to All Figure Page

Fig. 2

Ovo1 is required for the migration of NC-derived pigment precursors. Dorsal views, anterior to the left. (A,C,E,G,I) Controls; (B,D,F,H,J) Ovo1 morphants. Embryos were processed by wholemount in situ hybridization for expression of sox10 (A,B), mitfa (C,D), gch (E,F), dlx2 (G,H) and foxd3 (I,J). NC cells migrate in bilateral streams in control embryos (A), but aggregate in the dorsal midline of Ovo1 morphants (B, arrow). Pigment precursors, which express mitfa and gch at 28 hpf, form ectopic clumps in the dorsal midline in Ovo1 morphants (D,F arrows) when compared with wild-type controls (C,E). However, skeletogenic and glial precursors, which express dlx2 and foxd3 at 24 hpf, respectively, do not form clumps in the midline in Ovo1 morphants (G-J). mbh, midbrain-hindbrain boundary; ot, otic vesicle; pa, pharyngeal arches.

Expression Data

Genes:	dlx2a foxd3 gch2 mitfa sox10
Fish:	WT WT + MO2-ovol1a
Knockdown Reagent:	MO2-ovol1a
Anatomical Terms:	melanoblast neural crest cell otic vesicle xanthoblast
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO2-ovol1a
Knockdown Reagent:	MO2-ovol1a
Observed In:	axis melanoblast axis xanthoblast neural crest cell migration
Stage:	Prim-5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Development