Publication	Data		Fish	Anatomy
Ata et al., 2018	Fig. 4		WT + CRISPR2-tdgf1	eye fused with eye, abnormal forebrain protruding, abnormal head decreased size, abnormal
Tanaka et al., 2018	Fig. 5		tdgf1ko202/ko202 (AB)	eye fused with eye, abnormal prechordal plate ctslb expression absent, abnormal shield gsc expression decreased amount, abnormal
Liu et al., 2017	Fig. 2		tdgf1tz257/tz257	whole organism eaf1 expression decreased amount, abnormal whole organism eaf2 expression decreased amount, abnormal
	Fig. 3		tdgf1tz257/tz257	presumptive endoderm gata5 expression absent, abnormal presumptive endoderm sox32 expression absent, abnormal
Montague et al., 2017	Fig. 2		tdgf1tz257/tz257	hypoblast sox32 expression decreased amount, abnormal margin gsc expression absent, abnormal margin lft1 expression absent, abnormal margin tbxta expression decreased amount, abnormal mesendoderm development decreased process quality, abnormal
Deshwar et al., 2016	Fig. 2		WT + MO1-tdgf1	nodal signaling pathway decreased occurrence, abnormal
	Fig. 3		WT + MO1-tdgf1	larval heart development decreased process quality, abnormal
Liu et al., 2016	Fig. 1		tdgf1tz257/tz257	germ ring fscn1a expression absent, abnormal margin dorsal region fscn1a expression absent, abnormal
Chen et al., 2015	Fig. 1		tdgf1m134/m134	axial hypoblast gsc expression absent, abnormal forerunner cell group rbp7a expression absent, abnormal margin aldh1a2 expression decreased amount, abnormal midbrain posterior region rbp7a expression increased amount, abnormal shield gsc expression absent, abnormal whole organism aldh1a2 expression decreased amount, abnormal whole organism rbp7a expression increased amount, abnormal
Dubrulle et al., 2015	Fig. 1		tdgf1tz257/tz257	endoderm absent, abnormal head mesoderm absent, abnormal trunk mesoderm absent, abnormal
Kobitski et al., 2015	Fig. 5		tdgf1m134/m134; kca66Tg	epiboly decreased duration, abnormal eye fused with eye, abnormal mesoderm morphology, abnormal prechordal plate morphology, abnormal whole organism altered number of cell, abnormal whole organism has extra parts of type cell, abnormal whole organism has fewer parts of type cell, abnormal
Ma et al., 2015	Fig. 1		tdgf1m134/m134	eye fused with eye, abnormal neural tube closure decreased occurrence, abnormal pineal complex elongated, abnormal pineal complex shape, abnormal pineal complex split bilaterally, abnormal whole organism anterior-posterior axis curved, abnormal
	Fig. 4		tdgf1m134/m134	eye fused with eye, abnormal head shape, abnormal lens fused with lens, abnormal
Ma et al., 2015	Fig. 3		tdgf1tz257/tz257	neuroectoderm anterior region otx2b expression decreased amount, abnormal neuroectoderm anterior region sox2 expression decreased amount, abnormal neuroectoderm posterior region hoxb1b expression decreased distribution, abnormal
	Fig. 4		tdgf1tz257/tz257	whole organism Ab3-smad2/3 labeling decreased amount, abnormal
Moreno-Ayala et al., 2015	Fig. S6		WT + MO1-tdgf1 + MO4-tp53	whole organism physical object quality, abnormal
Araya et al., 2014	Fig. 1		tdgf1tz257/tz257	neural tube morphology, abnormal
	Fig. 2		tdgf1tz257/tz257; knu3Tg	neural tube cell division cellular spatiotemporal quality, abnormal neural tube morphology, abnormal
	Fig. 7		tdgf1tz257/tz257	neural plate cell migration process quality, abnormal neural plate morphogenesis process quality, abnormal
	Fig. 8		tdgf1tz257/tz257	neural keel malformed, abnormal neural plate cell motility process quality, abnormal neural plate morphogenesis process quality, abnormal
	Fig. 9		tdgf1tz257/tz257	neural tube morphology, abnormal
Terashima et al., 2014	Fig. 2		tdgf1tz257/tz257	germ ring poorly differentiated, abnormal shield poorly differentiated, abnormal
Huang et al., 2013	Fig. 3		tdgf1tz257/tz257	convergent extension involved in nephron morphogenesis process quality, abnormal pronephric glomerulus morphogenesis process quality, abnormal
	Fig. 7		tdgf1tz257/tz257	cardioblast migration to the midline involved in heart field formation process quality, abnormal
Lenhart et al., 2013	Fig. 2		tdgf1tz257/tz257	heart jogging process quality, abnormal heart tube bilateral symmetry, abnormal
O'Neill et al., 2013	Fig. 3		WT + MO1-tdgf1 ,   WT + MO1-tdgf1 + MO4-tp53	tail bud increased size, abnormal
Liu et al., 2011	Fig. 3		tdgf1tz257/tz257	whole organism acy1 expression decreased amount, abnormal whole organism ascl1a expression increased amount, abnormal whole organism ba1l expression decreased amount, abnormal whole organism cited2 expression increased amount, abnormal whole organism crygs4 expression decreased amount, abnormal whole organism cyp27c1 expression decreased amount, abnormal whole organism dusp4 expression decreased amount, abnormal whole organism fbxl4 expression increased amount, abnormal whole organism hspbap1 expression increased amount, abnormal whole organism klhl26 expression increased amount, abnormal whole organism nab1a expression increased amount, abnormal whole organism nudt9 expression decreased amount, abnormal whole organism ptf1a expression decreased amount, abnormal whole organism rbm12bb expression decreased amount, abnormal whole organism rfxank expression increased amount, abnormal whole organism syt11a expression increased amount, abnormal whole organism xkr9 expression increased amount, abnormal whole organism zdhhc14 expression decreased amount, abnormal whole organism zgc:162698 expression decreased amount, abnormal
Slagle et al., 2011	Fig. 5		tdgf1tz257/tz257	dorsal/ventral pattern formation disrupted, abnormal extension aplastic, abnormal eye malformed, abnormal head hypoplastic, abnormal head morphology, abnormal post-vent region malformed, abnormal whole organism anterior-posterior axis curved ventral, abnormal
Untergasser et al., 2011	Fig. 6		tdgf1m134/m134	islet dkk3b expression absent, abnormal
Arboleda-Estudillo et al., 2010	Fig. 2		tdgf1unspecified/unspecified	cell-cell adhesion involved in mesendodermal cell migration disrupted, abnormal lateral mesoderm mesodermal cell misrouted, abnormal
Kim et al., 2009	Fig. 3		tdgf1m134/m134	forebrain development disrupted, abnormal forebrain morphology, abnormal
	Fig. 4		tdgf1m134/m134	forebrain development disrupted, abnormal forebrain morphology, abnormal
Pei et al., 2009	Fig. 7		tdgf1tz257/tz257	eye decreased amount, abnormal eye malformed, abnormal eye mislocalised, abnormal
Hashiguchi et al., 2008	Fig. 5		tdgf1tz257/tz257	eye fused with eye, abnormal post-vent region structure, abnormal
Latimer et al., 2008	Fig. 2		tdgf1tz257/tz257	endoderm aplastic, abnormal endoderm formation disrupted, abnormal
Pézeron et al., 2008	Fig. 3		tdgf1tz257/tz257 ,   tdgf1tz257/tz257	shield morphology, abnormal
	Fig. 5		tdgf1tz257/tz257	endoderm decreased size, abnormal forebrain aplastic, abnormal gut physical object quality, abnormal lens aplastic, abnormal prechordal plate decreased size, abnormal retina aplastic, abnormal
	Fig. 6		tdgf1tz257/tz257	endoderm aplastic, abnormal
Bennett et al., 2007	Fig. S2		tdgf1tz257/tz257	endoderm aplastic, abnormal eye fused with eye, abnormal head mesoderm aplastic, abnormal trunk mesoderm aplastic, abnormal
Hagos et al., 2007	Fig. 3		tdgf1tz257/tz257	eye fused with eye, abnormal
	Fig. 6		tdgf1tz257/tz257	endoderm aplastic, abnormal mesoderm aplastic, abnormal
Nechiporuk et al., 2007	Fig. 4		tdgf1tz257/tz257	epibranchial placode morphology, abnormal facial placode morphology, abnormal glossopharyngeal placode morphology, abnormal peripheral nervous system development disrupted, abnormal
	Fig. S3		tdgf1tz257/tz257	mesoderm development disrupted, abnormal mesoderm morphology, abnormal rhombomere 4 development disrupted, abnormal rhombomere 4 morphology, abnormal
Van Raay et al., 2007	Fig. 2		tdgf1tz257/tz257 (AB)	whole organism wholly ventralized, abnormal
Phenotype Annotation (1994-2006)	Fig. for (m134)		tdgf1m134/m134 (AB)	anatomical system quality, abnormal eye quality, abnormal floor plate quality, abnormal hatching gland quality, abnormal heart quality, abnormal nervous system quality, abnormal sensory system quality, abnormal whole organism lethal (sensu genetics), abnormal
	Fig. for (tz257)		tdgf1tz257/tz257	brain decreased size, abnormal gastrulation with mouth forming second quality, abnormal whole organism lethal (sensu genetics), abnormal
Xiong et al., 2006	Fig. 1		tdgf1tz257/tz257	embryo development paedomorphic growth, abnormal
	Fig. S11		tdgf1tz257/tz257	dorsal/ventral pattern formation disrupted, abnormal head morphology, abnormal post-vent region malformed, abnormal
Schäfer et al., 2005	Fig. 4		tdgf1m134/m134	medial floor plate aplastic, abnormal
Biemar et al., 2001	Fig. 6		tdgf1m134/m134 (AB)	endocrine pancreas development decreased process quality, abnormal pancreatic bud lacks all parts of type pancreatic B cell, abnormal
Kudoh et al., 2001	Fig. 3		tdgf1unspecified/unspecified	immature eye decreased amount, abnormal immature eye malformed, abnormal
Piotrowski et al., 2000	Fig. 8		tdgf1unspecified/unspecified	mandibular neural crest fused with hyoid neural crest, abnormal neural crest cell migration disrupted, abnormal
Schilling et al., 1999	Fig. 5		tdgf1m134/m134 (AB)	determination of digestive tract left/right asymmetry decreased process quality, abnormal determination of heart left/right asymmetry decreased process quality, abnormal heart tube bilateral symmetry, abnormal intestinal bulb primordium bilateral symmetry, abnormal
Schier et al., 1997	Fig. 1		tdgf1m134/m134 (AB)	eye fused with eye, abnormal hatching gland aplastic, abnormal notochord anterior region absent, abnormal notochord decreased thickness, abnormal notochord undulate, abnormal
	Fig. 6		tdgf1m134/m134 (AB)	gut aplastic, abnormal
	Fig. 8		tdgf1m134/m134 (AB)	eye fused with eye, abnormal prechordal plate aplastic/hypoplastic, abnormal
Hammerschmidt et al., 1996	Fig. 1		tdgf1tz257/tz257	axis decreased length, abnormal extension decreased length, abnormal extension increased thickness, abnormal eye fused with eye, abnormal floor plate absent, abnormal head decreased size, abnormal notochord undulate, abnormal polster aplastic, abnormal post-vent region curved ventral, abnormal somite increased width, abnormal tail bud increased size, abnormal telencephalon aplastic, abnormal
	Fig. 2		tdgf1tz257/tz257	cell migration involved in gastrulation disrupted, abnormal hatching gland aplastic, abnormal hatching gland cell absent, abnormal neuroectoderm morphology, abnormal olfactory placode aplastic, abnormal optic stalk morphology, abnormal prechordal plate aplastic, abnormal presumptive dorsal mesoderm morphology, abnormal
Malicki et al., 1996	Fig. 3		tdgf1m134/m134 (AB)	eye fused with eye, abnormal retina layer formation disrupted, abnormal retina stratification, abnormal
	Table 1		tdgf1m134/m134 (AB)	brain morphology, abnormal spinal cord morphology, abnormal
Schier et al., 1996	Fig. 4		tdgf1m134/m134 (AB)	eye fused with eye, abnormal floor plate decreased size, abnormal hypothalamus decreased size, abnormal neuroectoderm morphology, abnormal
Solnica-Krezel et al., 1996	Fig. 1		tdgf1m134/m134 (AB)	hatching gland cell absent, abnormal notochord morphology, abnormal trunk curved ventral, abnormal whole organism anterior-posterior axis decreased length, abnormal
	Fig. 3		tdgf1m134/m134 (AB)	anterior axial hypoblast increased thickness, abnormal axis decreased length, abnormal polster absent, abnormal
	Fig. T1		tdgf1m134/m134 (AB)	central nervous system ventral region decreased size, abnormal eye fused with eye, abnormal floor plate decreased size, abnormal prechordal plate aplastic, abnormal
Stemple et al., 1996	Fig. T1		tdgf1m134/m134 (AB)	eye fused with eye, abnormal floor plate decreased size, abnormal notochord curved ventral, abnormal