ZFIN Morpholino: MO1-llgl2

Target Location

Genome Build: GRCz11Chromosome: 12

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-llgl2

No data available

Phenotype

Phenotype resulting from MO1-llgl2

Phenotype	Fish	Figures
brain hydrocephalic, abnormal	AB/TU + MO1-llgl2	Fig. 1 from Tay et al., 2013
brain elovl6 expression spatial pattern, abnormal	AB/TU + MO1-llgl2	Fig. 7 from Ji et al., 2016
brain right side elovl6 expression mislocalised, abnormal	AB/TU + MO1-llgl2	Fig. 7 from Ji et al., 2016
determination of heart left/right asymmetry decreased process quality, abnormal	AB/TU + MO1-llgl2	Fig. 3 from Tay et al., 2013
determination of left/right asymmetry in nervous system disrupted, abnormal	AB/TU + MO1-llgl2	Fig. 7 from Ji et al., 2016

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Phenotype of all Fish created by or utilizing MO1-llgl2

Phenotype	Fish	Conditions	Figures
eye photoreceptor cell alignment eye photoreceptor cell, abnormal	llgl2^to6/to6 + MO1-llgl2	standard conditions	Fig. 5 from Kujawski et al., 2019
retina morphology, abnormal	llgl2^to6/to6 + MO1-llgl2	standard conditions	Fig. 6 from Kujawski et al., 2019
retinal outer nuclear layer morphology, abnormal	llgl2^to6/to6 + MO1-llgl2	standard conditions	Fig. 5 from Kujawski et al., 2019
eye photoreceptor cell mislocalised, abnormal	llgl2^to6/to6 + MO1-llgl2	standard conditions	Fig. 6 from Kujawski et al., 2019
retinal photoreceptor layer disorganized, abnormal	llgl2^to6/to6 + MO1-llgl2	standard conditions	Fig. 7 from Kujawski et al., 2019

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Citations

Include unpublished citations

Hatzold, J., Nett, V., Brantsch, S., Zhang, J.L., Armistead, J., Wessendorf, H., Stephens, R., Humbert, P.O., Iden, S., Hammerschmidt, M. (2023) Matriptase-dependent epidermal pre-neoplasm in zebrafish embryos caused by a combination of hypotonic stress and epithelial polarity defects. PLoS Genetics. 19:e1010873e1010873
Kujawski, S., Sonawane, M., Knust, E. (2019) penner/lgl2 is required for the integrity of the photoreceptor layer in the zebrafish retina. Biology Open. 8(4):
Dasgupta, A., Merkel, M., Clark, M.J., Jacob, A.E., Dawson, J.E., Manning, M.L., Amack, J.D. (2018) Cell volume changes contribute to epithelial morphogenesis in zebrafish Kupffer's vesicle. eLIFE. 7
Hatzold, J., Beleggia, F., Herzig, H., Altmüller, J., Nürnberg, P., Bloch, W., Wollnik, B., Hammerschmidt, M. (2016) Tumor suppression in basal keratinocytes via dual non-cell-autonomous functions of a Na,K-ATPase beta subunit. eLIFE. 5:e14277
Ji, Y., Buel, S.M., Amack, J.D. (2016) Mutations in zebrafish pitx2 model congenital malformations in Axenfeld-Rieger syndrome but do not disrupt left-right placement of visceral organs. Developmental Biology. 416(1):69-81
Westcot, S.E., Hatzold, J., Urban, M.D., Richetti, S.K., Skuster, K.J., Harm, R.M., Lopez Cervera, R., Umemoto, N., McNulty, M.S., Clark, K.J., Hammerschmidt, M., Ekker, S.C. (2015) Protein-Trap Insertional Mutagenesis Uncovers New Genes Involved in Zebrafish Skin Development, Including a Neuregulin 2a-Based ErbB Signaling Pathway Required during Median Fin Fold Morphogenesis. PLoS One. 10:e0130688
Tay, H.G., Schulze, S.K., Compagnon, J., Foley, F.C., Heisenberg, C.P., Yost, H.J., Abdelilah-Seyfried, S., and Amack, J.D. (2013) Lethal giant larvae 2 regulates development of the ciliated organ Kupffer's vesicle. Development (Cambridge, England). 140(7):1550-1559
Dodd, M.E., Hatzold, J., Mathias, J.R., Walters, K.B., Bennin, D.A., Rhodes, J., Kanki, J.P., Look, A.T., Hammerschmidt, M., and Huttenlocher, A. (2009) The ENTH domain protein Clint1 is required for epidermal homeostasis in zebrafish. Development (Cambridge, England). 136(15):2591-2600
Hava, D., Forster, U., Matsuda, M., Cui, S., Link, B.A., Eichhorst, J., Wiesner, B., Chitnis, A., and Abdelilah-Seyfried, S. (2009) Apical membrane maturation and cellular rosette formation during morphogenesis of the zebrafish lateral line. Journal of Cell Science. 122(Pt 5):687-695
Sonawane, M., Martin-Maischein, H., Schwarz, H., and Nüsslein-Volhard, C. (2009) Lgl2 and E-cadherin act antagonistically to regulate hemidesmosome formation during epidermal development in zebrafish. Development (Cambridge, England). 136(8):1231-1240

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