FIGURE

Fig. 6

ID

ZDB-FIG-260322-29

Publication

Bakker-van Bugnum et al., 2026 - A zebrafish multimodal toolbox to study the blood-brain barrier in health and disease

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Fig. 6

Microscopical analysis of plvapb: EGFP expression in larval brains under hyperglycemic conditions. Representative maximum intensity projection of a confocal z-stack showing Tg(plvapb: EGFP; kdrl: ras-mCherry) zebrafish larvae at 4 dpf (a) and 5 dpf (c) to visualize plvapb: EGFP expression (green) in 0 mM glucose controls, 130 mM mannitol-exposed larvae and after hyperglycemia (130 mM glucose). Vasculature is shown in magenta. Scale bars: 100 μm. Quantification of vessels segments positive for GFP in the brain parenchymal vasculature, indicating PLVAP expression, at 4 dpf (b) and 5 dpf (d).

Expression Data

Genes:	EGFP mCherry
Fish:	s896Tg/s896Tg; ulb40Tg/ulb40Tg
Condition:	chemical treatment by environment: glucose
Anatomical Term:	brain vasculature
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	s896Tg/s896Tg; ulb40Tg/ulb40Tg
Condition:	chemical treatment by environment: glucose
Observed In:	brain vasculature hindbrain regulation of blood-brain barrier permeability midbrain regulation of blood-brain barrier permeability
Stage:	Day 5

Phenotype Detail

Acknowledgments

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