FIGURE
Fig. 1
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- ZDB-FIG-250813-22
- Publication
- Halford et al., 2025 - TMEM63A, associated with hypomyelinating leukodystrophies, is an evolutionarily conserved regulator of myelination
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Fig. 1
HLD19-associated TMEM63A mutations are LOF. (A) Topology map of TMEM63A indicating LOF mutation sites. (B) Representative traces of stretch-activated currents induced by negative pipette pressure from HEK-P1KO cells transfected with WT TMEM63A or the indicated mutant. Pressure stimulus trace is illustrated above. (C) Maximal stretch-activated currents (Imax) recorded from WT and variants (n = 18 for WT, n = 10 for mutant constructs, across multiple transfections, One-way ANOVA, Kruskal–Wallis test of multiple comparisons). |
Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
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