FIGURE

Fig. 2

ID

ZDB-FIG-250611-53

Publication

Hawkey-Noble et al., 2025 - The P4-phospholipid flippase Atp11a is required for maintenance of eye and ear structure in zebrafish

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Fig. 2

Reduced number of stereocilia in atp11a mutants. (A) Phalloidin staining of F-actin filaments in the hair cells of the atp11anl1005 zebrafish inner ear at 5 dpf, illustrating significant hair cell loss in the medial crista (MC), posterior crista (PC) and macula (PM), as well as the anterior macula (AM), resulting in an overall decrease in the inner ear. (B) Hair cell quantification for the anterior crista (AC), anterior macular, medial crista, posterior crista and posterior macula demonstrates a reduction in stereocilia in heterozygous and homozygous mutants. Data are mean±s.e.m. with significance testing (*P<0.05, **P<0.01, ***P<0.001) calculated using a one-factor ANOVA with Tukey's post-hoc analysis for multiple comparisons. Wild type, n=17; heterozygous, n=22; homozygous mutant, n=7.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	atp11a^{nfl1005/nfl1005} (AB) atp11a^nfl1005/+ (AB)
Observed In:	anterior crista stereocilium anterior macula stereocilium lateral crista stereocilium posterior crista stereocilium posterior macula stereocilium
Stage:	Day 5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Cell Sci.