FIGURE

Fig. 1

ID

ZDB-FIG-250611-52

Publication

Hawkey-Noble et al., 2025 - The P4-phospholipid flippase Atp11a is required for maintenance of eye and ear structure in zebrafish

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Fig. 1

Generation of atp11a loss-of-function mutants. (A–C) Two mutant strains were isolated using the same gRNA, creating a 7 bp deletion (GTTCTGT) highlighted by the blue bar and a 5 bp deletion (TAAAG) highlighted by the red bar. (D–K) At both 4 and 6 dpf, larvae are morphologically wild type, inflate their swim bladders and have reduced pigment. (L–N) In situ hybridization using an antisense atp11a probe demonstrates reduced transcript levels in heterozygous and homozygous mutant embryos at 24 hpf.

Expression Data

Gene:	atp11a
Fish:	AB atp11a^{nfl1007/nfl1007} (AB) atp11a^nfl1007/+ (AB)
Anatomical Term:	head
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	atp11a^{nfl1005/nfl1005} (AB) atp11a^{nfl1007/nfl1007} (AB)
Observed In:	head swim bladder whole organism
Stage Range:	Prim-5 to Day 6

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Cell Sci.