FIGURE

Figure 7

ID

ZDB-FIG-250417-114

Publication

Oyarbide et al., 2025 - Reduced EIF6 dosage attenuates TP53 activation in models of Shwachman-Diamond syndrome

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Figure 7

Tp53 activation in SDS patient–derived cells.

Western blots and quantification of (A) LCLs and (B) BM-MNCs. EIF6 mRNA (C) and protein (D) levels in 3 different siRNAs. (E) EIF6 mRNA levels in patients with SDS with and without siRNA (F) TP53 and CDKN1a mRNA levels are decreased after siRNA in patients with SDS. (G) Western blots showing decrease in TP53 levels after EIF6 knockdown using 3 different siRNAs. (H) TP53 protein quantification. Data represent the mean ± SEM. HD, healthy donor; NC, negative control.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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