FIGURE

Figure 4

ID

ZDB-FIG-250417-111

Publication

Oyarbide et al., 2025 - Reduced EIF6 dosage attenuates TP53 activation in models of Shwachman-Diamond syndrome

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Figure 4

Tp53 pathway activation in eif6 mutants does not affect survival rates.

RT-qPCR analysis of tp53 and its targets of WT and eif6 KO on the (A) tp53^+/+ and (B) tp53^M214K/M214K backgrounds. (C) Scheme of the double-heterozygote crosses (eif6^+/–tp53^+/M214K). (D) Percentage of survival for double-heterozygote crosses of eif6^+/–tp53^+/M214K at 8 and 15 dpf. (E) RT-qPCR analysis of tp53 and its targets (*P < 0.05, **P < 0.01, and ***P < 0.001, by 1-way ANOVA), and (F) UPR markers in WT and eif6^ms/ms zebrafish at 5 dpf (*P < 0.05 and ***P < 0.001, by 2-tailed t test). Data represent the mean ± SEM.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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