FIGURE

Figure 5

ID

ZDB-FIG-250417-112

Publication

Oyarbide et al., 2025 - Reduced EIF6 dosage attenuates TP53 activation in models of Shwachman-Diamond syndrome

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Figure 5

Partial rescue of sbds KO with 1 copy of the WT eif6 allele.

(A) Scheme showing the incrossing of 2 double-heterozygotes (eif6^+/– sbds^+/–). (B) Genotype percentages at 15 dpf of an incrossing of double-heterozygotes. (C) Western blots showing Eif6 accumulation in sbds KO fish with only 1 copy of the eif6 WT allele (eif6^+/–). (D) Western blot quantification of Eif6 protein expression. (E) Sudan black staining to detect the number of neutrophils in 10 dpf siblings. Scale bars: 200 μm and 50 μm. Data represent the mean ± SEM.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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