Fig. 6
- ID
- ZDB-FIG-240229-28
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- Altbürger et al., 2023 - Neurog1 and Olig2 integrate patterning and neurogenesis signals in development of zebrafish dopaminergic and glutamatergic dual transmitter neurons
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olig2 expression is regulated by Shh signaling and acts upstream of her2. (A, B) her2 expression in (B) olig2m1317/m1317 mutants compared to (A) wildtype siblings at 48 hpf. The expression of her2 is increased in the hypothalamus/posterior tuberculum in olig2m1317/m1317 mutant embryos (black arrowheads). (C1-D3) her2 expression (green) relative to neurog1 expression (magenta) in (D1-D3) olig2m1317/m1317 mutants compared to (C1–C3) wildtype siblings at 48 hpf. her2 expression is increased whereas neurog1 expression is decreased in olig2m1317/m1317 mutant embryos (white arrowheads). (E–H) olig2 expression at 48 hpf in (F,H) embryos treated with Cyclopamine between 24 and 48 hpf, compared to (E,G) control embryos treated with ethanol. olig2 expression is reduced in the hypothalamus/posterior tuberculum and in the thalamus upon inhibition of Shh signaling by Cyclopamine. The phenotypes were observed in N/N (number of embryos with phenotype shown in figure panel/total number of embryos analyzed): (A) 4/4; (B) 7/7; (C1–C3) 4/4; (D1-D3) 4/4; (E,G) 15/15; (F,H) 15/15. Abbreviations: H, hypothalamus; HB, hindbrain; PT, posterior tuberculum; Tel, telencephalon. All images show lateral views, except E, F showing dorsal views; (A and B) show single optical planes; (C1-D3) are 340 μm maximum intensity projections. Anterior is to the left. Scale bars: 100 μm. |
Reprinted from Developmental Biology, 505, Altbürger, C., Rath, M., Armbruster, D., Driever, W., Neurog1 and Olig2 integrate patterning and neurogenesis signals in development of zebrafish dopaminergic and glutamatergic dual transmitter neurons, 859885-98, Copyright (2023) with permission from Elsevier. Full text @ Dev. Biol.