FIGURE

Figure 2

ID

ZDB-FIG-230228-12

Publication

Enders et al., 2023 - Impact of the Voltage-Gated Calcium Channel Antagonist Nimodipine on the Development of Oligodendrocyte Precursor Cells

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Figure 2

Oli-Neu cells show increased expression of myelin-related genes after PD 174265 treatment. (A,B) Staining of stimulated Oli-Neu cells treated with DMSO, 1 µM, or 10 µM nimodipine. Images show MBP (red)/Olig2 (green) (A) or MAG (B). Scale bars represent 100 µm. In n = 10 images, the MFI (C,F) and the area occupied by all cells per image in cm² (D,G) were measured. (E,H) mRNA expression of Mbp (E) and Mag (H). Data are presented as mean value ± standard deviation. All experiments were performed as n = 4 independent experiments. Kruskal–Wallis test was performed to test for statistical significance. * p ≤ $\leq$ 0.05 ** p ≤ $\leq$ 0.01. cm²: square centimeters; DAPI: 4′,6-diamidino-2-phenylindole; DMSO: dimethyl sulfoxide; MBP: myelin basic protein; MFI: mean fluorescent intensity; Nimo: nimodipine.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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