FIGURE

Figure 5

ID

ZDB-FIG-220827-27

Publication

Elfatih et al., 2022 - Analysis of incidental findings in Qatar genome participants reveals novel functional variants in LMNA and DSP

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Figure 5

Zebrafish LMNA model heart structure abnormalities. Modeling Qatar Genome Programme human LMNA cardiac variant produced abnormal heart chambers in LMNA zebrafish model. (A) Proportion of heart abnormalities, including valve defects and abnormal heart chamber shape in the four experimental groups. (B) LMNA zebrafish heart 3D structure at 72 hours post fertilization (hpf). Transgenic embryos (Tg:gata1: dsRed, cmlc2:eGFP), expressing red fluorescent red blood cells and green hearts) showing the abnormal cardiac chambers structure (Atrium: A, Ventricle: V). AV valve: Control (n = 3), lmna MO (n = 5), MO + LMNA^Variant (n = 14), and MO + LMNA^WT (n = 0). Ventricular shape: Control (n = 2), lmna MO (n = 14), MO + LMNA^Variant (n = 28), and MO + LMNA^WT (n = 5). Atrium shape: Control (n = 0), MO (n = 10), MO + LMNA^Variant (n = 16), and MO + LMNA^WT (n = 1).

Expression Data

Genes:	DsRed EGFP
Fish:	sd2Tg; zf3671Tg sd2Tg; zf3671Tg + MO6-lmna
Knockdown Reagent:	MO6-lmna
Anatomical Terms:	atrium cardiac ventricle nucleate erythrocyte
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	sd2Tg; zf3671Tg + MO6-lmna
Knockdown Reagent:	MO6-lmna
Observed In:	atrioventricular valve atrium cardiac ventricle
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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