FIGURE
Fig. 5
- ID
- ZDB-FIG-220615-45
- Publication
- Cosacak et al., 2022 - Single Cell/Nucleus Transcriptomics Comparison in Zebrafish and Humans Reveals Common and Distinct Molecular Responses to Alzheimer's Disease
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Fig. 5
Figure 5. Analysis of the differentially expressed genes in specific cell clusters. (A) Schematic representation of the analysis pipeline. Human cell clusters from EC and SFG are compared between Braak Stage 6 and 0, and zebrafish cell clusters were compared between amyloid-beta-42 injection versus controls. The common KEGG pathways for differentially expressed genes are shown in yellow, zebrafish-specific hits are blue, and human-specific hits are in green. The other category includes the hits that are present only in one human brain region, but not in the other. (B) Neuronal and astroglial cell clusters are compared for the KEGG pathway changes. Strikingly, the neuronal clusters in human and zebrafish respond to AD in a highly similar fashion in terms of altered KEGG pathways (B), while astroglia have more species-specific responses than common (C). See Datas S4 and S5.
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Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
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