Figure 7—figure supplement 1.

CVD-associated SNVs can be mapped to the orthologous medaka peptide sequence with high conservation and are expressed during heart development.

(a) Human (Hs) coding sequences for DAPK3, UBE2B, USP44, and PTPN11 around the missense mutations reported (Homsy et al., 2015; Zaidi et al., 2013), were obtained from the Ensemble genome browser and the orthologous medaka (Ol) sequences were mapped to these (release 103). (b) Gene expression data for medaka dapk3, ube2b, usp44, and ptpn11 at embryonic stages was extracted from Li et al., 2020 and plotted to show presence of transcript during heart development and the contribution of maternal transcripts, which dominate before zygotic genome activation at around stages 7–8 (32–64 cell stages; Kraeussling et al., 2011).

Expression Data

Expression Detail
Antibody Labeling
Phenotype Data

Phenotype Detail
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Elife