FIGURE

Figure 6—figure supplement 2

ID

ZDB-FIG-220313-11

Publication

Zhai et al., 2022 - Augmentation of progestin signaling rescues testis organization and spermatogenesis in zebrafish with the depletion of androgen signaling

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Figure 6—figure supplement 2

The upregulated fshβ contributes to the hypertrophic testis and enhanced spermatogenesis in the cyp17a1-/- fish and cyp17a1-/-;ar-/- fish at 6 months post-fertilization (mpf).

(A–E) Anatomical examination of the testes from control males, ar-/- males, cyp17a1-/- fish, cyp17a1-/-;ar-/- fish, and cyp17a1-/-;ar-/-;fshβ-/- fish at 6 mpf. Black and green arrows indicate the normal and decreased size of testes in control males and cyp17a1-/-;ar-/-;fshβ-/- fish, and ar-/- males, respectively, whereas the red arrows indicate the hypertrophic testis in the cyp17a1-/- fish and cyp17a1-/-;ar-/- fish. (F) Gridpoint Statistical Interpolation (GSI) from fish of the five genotypes at 6 mpf. The letters in bar chart (F) represent significant differences. (G–K) Histological analyses of the testes from control males, ar-/- males, cyp17a1-/- fish, cyp17a1-/-;ar-/- fish, and cyp17a1-/-;ar-/-;fshβ-/- fish at 6 mpf. Black and green letters indicate the normal and decreased number of spermatozoa (SZ) in control males and cyp17a1-/-;ar-/-;fshβ-/- fish, and ar-/- males, respectively, whereas the red letters indicate the increased number of SZ in the cyp17a1-/- fish and cyp17a1-/-;ar-/- fish.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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