FIGURE

Fig. 8.

ID

ZDB-FIG-220305-22

Publication

Baronio et al., 2021 - Abnormal brain development of monoamine oxidase mutant zebrafish and impaired social interaction of heterozygous fish

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Fig. 8.

Gene expression in adult mao^+/+ and mao^+/− fish. (A-F) Bar charts showing results from RT-qPCR analysis of shank3b (A), mecp2 (B), hrh3 (C), mao (D), vmat2 (E) and serta (F) in adult brains of the indicated genotype. A significant decrease in the expression of mao was detected in mao^+/− fish compared to mao^+/+ siblings. A significant upregulation in the expression of vmat2 was detected in mao^+/− fish compared to mao^+/+ siblings. (G,H) Dorsal views of whole-mount adult mao^+/+ (G) and mao^+/− (H) brains, anterior to the top, processed for serta RNA ISH. serta-positive neurons expressed in the ventral posterior tuberculum. (I,J) Ventral views of whole-mount adult mao^+/+ (I) and mao^+/− (J) brains, anterior to the right, processed for serta RNA ISH. serta-positive neurons expressed in the raphe nuclei and hindbrain. Data are mean±s.e.m. Unpaired, two-tailed Student's t-test was used for statistical analysis. *P<0.05, ***P<0.001. Scale bar: 75 μm

Expression Data

Genes:	hrh3 mao mecp2 shank3b slc6a4a slc18a2 (all 6)
Fish:	WT mao^sa31732/+
Anatomical Terms:	brain caudal tuberculum ventral region hindbrain raphe nucleus
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	mao^sa31732/+
Observed In:	brain
Stage:	Adult

Phenotype Detail

Acknowledgments

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