ZFIN is now using GRCz12tu for Genomic Data
Gene
shank3b
- ID
- ZDB-GENE-041210-74
- Name
- SH3 and multiple ankyrin repeat domains 3b
- Symbol
- shank3b Nomenclature History
- Previous Names
-
- si:dkey-153k10.1
- zs3.1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable ionotropic glutamate receptor binding activity and synaptic receptor adaptor activity. Acts upstream of or within intestinal motility; swimming behavior; and visual behavior. Predicted to be located in cytoplasm. Predicted to be active in dendritic spine and postsynaptic density. Predicted to colocalize with postsynaptic membrane. Is expressed in brain; forebrain; and midbrain. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in Phelan-McDermid syndrome and schizophrenia 15. Orthologous to human SHANK3 (SH3 and multiple ankyrin repeat domains 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Phelan-McDermid syndrome | Alliance | Phelan-McDermid syndrome | 606232 |
| schizophrenia 15 | Alliance | {Schizophrenia 15} | 613950 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| autism spectrum disorder | shank3bfdu201/fdu201 (TU) | standard conditions | Liu et al., 2018 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001452 | SH3 domain |
| Domain | IPR001478 | PDZ domain |
| Domain | IPR001660 | Sterile alpha motif domain |
| Domain | IPR041489 | PDZ domain 6 |
| Homologous_superfamily | IPR013761 | Sterile alpha motif/pointed domain superfamily |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
| Homologous_superfamily | IPR036034 | PDZ superfamily |
| Homologous_superfamily | IPR036770 | Ankyrin repeat-containing domain superfamily |
| Repeat | IPR002110 | Ankyrin repeat |
Domain Details Per Protein
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
shank3b-201
(1)
|
Ensembl | 4,812 nt | ||
| mRNA |
shank3b-202
(1)
|
Ensembl | 5,490 nt | ||
| mRNA |
shank3b-203
(1)
|
Ensembl | 637 nt | ||
| mRNA |
shank3b-204
(1)
|
Ensembl | 4,617 nt | ||
| mRNA |
shank3b-205
(1)
|
Ensembl | 4,554 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers