FIGURE

FIGURE 3

ID

ZDB-FIG-210902-27

Publication

Koh et al., 2021 - Fluorescence Correlation Spectroscopy Reveals Survival Motor Neuron Oligomerization but No Active Transport in Motor Axons of a Zebrafish Model for Spinal Muscular Atrophy

Other Figures

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FIGURE 3

Diffusion coefficient of mCherry-Smn in motor neurons under smn MO conditions. (A,B) Average diffusion coefficients, D_1, D₂ (μm²/s) of mCherry-Smn in motor neuron cell bodies under uninjected control and smn MO conditions. D₁ was not observed for mCherry-Smn under smn MO conditions. (C,D) Average diffusion coefficients, D_1, D₂ (μm²/s) of mCherry-Smn in axons for uninjected control and smn MO conditions. Error bars represent the SD. (^n.s.P > 0.05, ^****P < 0.0001). The numbers above the graph indicate the number of fish (number of points) the measurements were taken in.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ns12Tg/ns12Tg + MO1-smn1
Knockdown Reagent:	MO1-smn1
Observed In:	neuron protein transport neuron regulation of protein oligomerization
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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