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Fig. 8

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ZDB-FIG-210216-16

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Das et al., 2020 - Cortisol rapidly stimulates calcium waves in the developing trunk muscle of zebrafish

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Fig. 8

Fig. 8. Proposed model for the rapid cortisol action on [(Ca²⁺)i] in the developing trunk muscle (DTM) of zebrafish. We propose that cortisol-mediated rapid rise in [(Ca²⁺)i] occur via two pathways: i) A direct effect of cortisol by binding to the CRAC channel and modulating the pore (Orai-1) opening to allow extracellular Ca²⁺ (eCa²⁺) entry causing the rapid intracellular Ca²⁺ (iCa²⁺) rise, and ii) an indirect effect of cortisol that may include the activation of a yet unknown membrane GPCR resulting in either the gating of VGCC and/or the activation of PKA/PKC signaling leading to the release of Ca²⁺ from the sarcoplasmic reticulum (SR). The drop in SR Ca²⁺ stores activates the Ca²⁺ sensor STIM, which interacts with the CRAC channel to cause eCa²⁺ entry leading to a rise in [(Ca²⁺)i] in the DTM. Abbreviations: [(Ca²⁺)i] – cytosolic free calcium levels, CRAC- calcium release-activated Ca²⁺ channel, VGCC - voltage-gated Ca²⁺ channels, STIM-stromal interaction molecule, PKA-protein kinase A, PKC – protein kinase C, GPCR-G protein-coupled receptor.

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Reprinted from Molecular and Cellular Endocrinology, 520, Das, C., Faught, E., Vijayan, M.M., Cortisol rapidly stimulates calcium waves in the developing trunk muscle of zebrafish, 111067, Copyright (2020) with permission from Elsevier. Full text @ Mol. Cell. Endocrinol.