FIGURE

Fig. 6

ID

ZDB-FIG-200924-37

Publication

Oyarbide et al., 2020 - Loss of Sbds in zebrafish leads to neutropenia and pancreas and liver atrophy

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Fig. 6

(A and B) H&E staining of pancreas and digestive tract in starvation assays. (C) ORO staining for lipid accumulation in starved and fed fish for 10–15 or 15–21 dpf. A model of starvation was performed to determine size distribution and fin regeneration. Scale bars: 500 μm (left), 50 μm (right). (D) Survival rates and (E) size distribution in WT and mutants after starvation. Expression of (F) tp53 and (G) cdk1a show a dysregulation of cdkn1a in starved mutants. (H) Gene expression of lipid metabolism markers in starved WT fish. Statistical analysis was performed using the ANOVA and t test. *P < 0.05, **P < 0.001, ***P < 0.0001.

Expression Data

Genes:	cdkn1a fasn pparg srebf1 tp53
Fish:	WT sbds^nu132/nu132
Condition:	fasting
Anatomical Term:	whole organism
Stage:	Days 14-20

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT sbds^nu132/nu132
Condition:	fasting
Observed In:	blood vessel blood vessel lipid intestinal villus intestine intestine lipid droplet pancreas zymogen granule whole organism
Stage Range:	Days 14-20 to Days 21-29

Phenotype Detail

Acknowledgments

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