Gene

pparg

ID
ZDB-GENE-990415-213
Name
peroxisome proliferator-activated receptor gamma
Symbol
pparg Nomenclature History
Previous Names
  • PPAR[g]
  • ARF6 (1)
  • NR1C3 (1)
  • nr1c3 (1)
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Predicted to have several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II repressing transcription factor binding activity; and nuclear receptor transcription coactivator activity. Involved in triglyceride homeostasis. Predicted to localize to RNA polymerase II transcription regulator complex. Is expressed in several structures, including adipose tissue; digestive system; female organism; male organism; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); end stage renal disease; familial combined hyperlipidemia; lipodystrophy (multiple); and obesity. Orthologous to human PPARG (peroxisome proliferator activated receptor gamma).
Genome Resources
Note
None
Expression
All Expression Data
39 figures from 31 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pparg Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
familial partial lipodystrophy type 3 Alliance Insulin resistance, severe, digenic 604367
familial partial lipodystrophy type 3 Alliance Lipodystrophy, familial partial, type 3 604367
obesity Alliance Obesity, severe 601665
type 2 diabetes mellitus Alliance {Diabetes, type 2} 125853
Carotid intimal medial thickness 1 609338
[Obesity, resistance to]
Associated With pparg Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000536 Nuclear hormone receptor, ligand-binding domain
Domain IPR001628 Zinc finger, nuclear hormone receptor-type
Domain IPR022590 Peroxisome proliferator-activated receptor gamma, N-terminal
Family IPR001723 Nuclear hormone receptor
Family IPR003074 Peroxisome proliferator-activated receptor
Family IPR003077 Peroxisome proliferator-activated receptor gamma
Homologous_superfamily IPR013088 Zinc finger, NHR/GATA-type
Homologous_superfamily IPR035500 Nuclear hormone receptor-like domain superfamily
Domain Details Per Protein
Protein Length Nuclear hormone receptor Nuclear hormone receptor, ligand-binding domain Nuclear hormone receptor-like domain superfamily Peroxisome proliferator-activated receptor Peroxisome proliferator-activated receptor gamma Peroxisome proliferator-activated receptor gamma, N-terminal Zinc finger, NHR/GATA-type Zinc finger, nuclear hormone receptor-type
UniProtKB:Q1L687 308
UniProtKB:A6XMH6 527
UniProtKB:A0A140LGV8 116
UniProtKB:A0A140LGM0 92
UniProtKB:O42550 44
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations