Gene

pparg

ID
ZDB-GENE-990415-213
Name
peroxisome proliferator-activated receptor gamma
Symbol
pparg Nomenclature History
Previous Names
  • PPAR[g]
  • ARF6 (1)
  • NR1C3 (1)
  • nr1c3 (1)
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Predicted to have several functions, including DNA-binding transcription factor activity; RNA polymerase II repressing transcription factor binding activity; and nuclear receptor transcription coactivator activity. Involved in triglyceride homeostasis. Predicted to localize to RNA polymerase II transcription factor complex. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); end stage renal failure; familial combined hyperlipidemia; lipodystrophy (multiple); and obesity. Is expressed in several structures, including adipose tissue; digestive system; female organism; male organism; and pleuroperitoneal region. Orthologous to human PPARG (peroxisome proliferator activated receptor gamma).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
48 figures from 39 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
7 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pparg Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
familial partial lipodystrophy type 3 Alliance Insulin resistance, severe, digenic 604367
familial partial lipodystrophy type 3 Alliance Lipodystrophy, familial partial, type 3 604367
obesity Alliance Obesity, severe 601665
type 2 diabetes mellitus Alliance {Diabetes, type 2} 125853
Carotid intimal medial thickness 1 609338
[Obesity, resistance to]
Associated With pparg Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000536 Nuclear hormone receptor, ligand-binding domain
Domain IPR001628 Zinc finger, nuclear hormone receptor-type
Domain IPR022590 Peroxisome proliferator-activated receptor gamma, N-terminal
Family IPR001723 Nuclear hormone receptor
Family IPR003074 Peroxisome proliferator-activated receptor
Family IPR003077 Peroxisome proliferator-activated receptor gamma
Homologous_superfamily IPR013088 Zinc finger, NHR/GATA-type
Homologous_superfamily IPR035500 Nuclear hormone receptor-like domain superfamily
Domain Details Per Protein
Protein Length Nuclear hormone receptor Nuclear hormone receptor, ligand-binding domain Nuclear hormone receptor-like domain superfamily Peroxisome proliferator-activated receptor Peroxisome proliferator-activated receptor gamma Peroxisome proliferator-activated receptor gamma, N-terminal Zinc finger, NHR/GATA-type Zinc finger, nuclear hormone receptor-type
UniProtKB:A0A140LGM0 92
UniProtKB:A0A140LGV8 116
UniProtKB:O42550 44
UniProtKB:A6XMH6 527
UniProtKB:Q1L687 308
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations