ZFIN is now using GRCz12tu for Genomic Data
Gene

tp53

ID
ZDB-GENE-990415-270
Name
tumor protein p53
Symbol
tp53 Nomenclature History
Previous Names
  • p53 (1)
  • brp53
  • drp53
  • etID22686.5 (1)
  • fb40d06
  • wu:fb40d06 (1)
  • zgc:111919
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Genome Assembly
GRCz12tu
Annotation Status
Current
Description
Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in regulation of transcription by RNA polymerase II. Acts upstream of or within with a positive effect on transforming growth factor beta receptor signaling pathway. Acts upstream of or within several processes, including hemopoiesis; intracellular signal transduction; and regulation of macromolecule metabolic process. Located in chromatin. Is expressed in several structures, including digestive system; hematopoietic system; musculature system; nervous system; and reproductive system. Used to study Li-Fraumeni syndrome; aggressive NK-cell leukemia; angiosarcoma; cancer; and malignant peripheral nerve sheath tumor. Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome (multiple); carcinoma (multiple); hematologic cancer (multiple); open-angle glaucoma (multiple); and pancreatic cancer (multiple). Orthologous to human TP53 (tumor protein p53).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
260 figures from 211 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
55 figures from 40 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tp53 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
adrenocortical carcinoma Alliance {Adrenocortical carcinoma, pediatric} 202300
breast cancer Alliance Breast cancer, somatic 114480
choroid plexus papilloma Alliance {Choroid plexus papilloma} 260500
colorectal cancer Alliance {Colorectal cancer} 114500
hepatocellular carcinoma Alliance Hepatocellular carcinoma, somatic 114550
Li-Fraumeni syndrome 1 Alliance Li-Fraumeni syndrome 151623
nasopharynx carcinoma Alliance Nasopharyngeal carcinoma, somatic 607107
osteosarcoma Alliance {Osteosarcoma} 259500
pancreatic carcinoma Alliance Pancreatic cancer, somatic 260350
Bone marrow failure syndrome 5 618165
{Basal cell carcinoma 7} 614740
{Glioma susceptibility 1} 137800
Associated With tp53 Via Experimental Models
Human Disease Fish Conditions Citations
malignant peripheral nerve sheath tumor tp53zdf1/zdf1 standard conditions Nissim et al., 2019
cancer tp53fb105/fb105 standard conditions Ignatius et al., 2018
angiosarcoma tp53fb105/fb105 standard conditions Ignatius et al., 2018
Li-Fraumeni syndrome tp53zy7/+ (AB) standard conditions Parant et al., 2010
Li-Fraumeni syndrome tp53zy7/zy7 (AB) standard conditions Parant et al., 2010
aggressive NK-cell leukemia tp53fb105/fb105 standard conditions Ignatius et al., 2018
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR010991 p53, tetramerisation domain
Domain IPR011615 p53, DNA-binding domain
Family IPR002117 p53 tumour suppressor family
Homologous_superfamily IPR008967 p53-like transcription factor, DNA-binding domain superfamily
Homologous_superfamily IPR012346 p53/RUNT-type transcription factor, DNA-binding domain superfamily
Homologous_superfamily IPR036674 p53-like tetramerisation domain superfamily
Domain Details Per Protein
Protein Additional Resources Length p53, DNA-binding domain p53-like tetramerisation domain superfamily p53-like transcription factor, DNA-binding domain superfamily p53/RUNT-type transcription factor, DNA-binding domain superfamily p53, tetramerisation domain p53 tumour suppressor family
UniProtKB:A0A8M2BCD8 InterPro 370
UniProtKB:A0A8M2BCE6 InterPro 257
UniProtKB:B0R0M3 InterPro 369
UniProtKB:P79734 InterPro PDB 373
UniProtKB:A0A0B4VFS7 InterPro 261
UniProtKB:G1K2L5 InterPro PDB 374
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA tp53-201 (1)
Ensembl
Ensembl 2,211 nt
ZFIN BLAST
mRNA tp53-203 (1)
Ensembl
Ensembl 2,204 nt
ZFIN BLAST
mRNA tp53-206 (1)
Ensembl
Ensembl 2,208 nt
ZFIN BLAST
mRNA tp53-207 (1)
Ensembl
Ensembl 1,195 nt
ZFIN BLAST
mRNA tp53-208 (1)
Ensembl
Ensembl 1,956 nt
ZFIN BLAST
ncRNA tp53-002 (1)
Ensembl
Ensembl 802 nt
ZFIN BLAST
ncRNA tp53-003 (1)
Ensembl
Ensembl 579 nt
ZFIN BLAST
ncRNA tp53-004 (1)
Ensembl
Ensembl 748 nt
ZFIN BLAST
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-tp53 monoclonal Mouse
  • IHC
  • WB
 4
Ab10-tp53 monoclonal Mouse
  • IHC
  • WB
 9
Ab11-tp53 monoclonal IgG Mouse
  • IHC
  • WB
 Abcam plc
19
Ab2-tp53 monoclonal IgG1 Mouse
  • IHC
  • WB
 3
Ab6-tp53 monoclonal Mouse
  • WB
 2
Ab7-tp53 polyclonal Rabbit
  • WB
 AnaSpec
10
Ab3-tp53 monoclonal IgG1 Mouse
  • WB
 6
Ab4-tp53 polyclonal Rabbit
1
Ab9-tp53 polyclonal Rabbit
1
Plasmids
Constructs
Marker Relationships
Sequences
Genome Browsers
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations
Your Input Welcome
We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.
Please check the highlighted fields and try again.
Thank you for submitting comments. Your input has been emailed to ZFIN curators who may contact you if additional information is required.
Oops. Something went wrong. Please try again later.