Gene
fasn
- ID
- ZDB-GENE-030131-7802
- Name
- fatty acid synthase
- Symbol
- fasn Nomenclature History
- Previous Names
-
- FAS (1)
- fj34h12
- wu:fj34h12
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable fatty acid synthase activity. Acts upstream of or within response to (R)-carnitine. Predicted to be active in cytoplasm. Is expressed in adipose tissue; digestive system; female organism; male organism; and muscle. Orthologous to human FASN (fatty acid synthase).
- Genome Resources
- Note
-
Transcripts from ENSDARG00000087657 in Ensembl GRCz11 are associated with ccdc57 and fasn. fasn-202 (ENSDART00000124982) should be associated with ccdc57. Other transcripts belong with fasn. Alternate gene (haplotype) in GRCz11 is ENSDARG00000113553.
- Comparative Information
-
- All Expression Data
- 70 figures from 62 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | ACP-like superfamily | Acyl transferase/acyl hydrolase/lysophospholipase | Acyl transferase domain | Acyl transferase domain superfamily | Alpha/Beta hydrolase fold | Beta-ketoacyl synthase, active site | Beta-ketoacyl synthase, C-terminal | Beta-ketoacyl synthase-like, N-terminal | Fatty acid synthase, pseudo-KR domain | GroES-like superfamily | Malonyl-CoA ACP transacylase, ACP-binding | NAD(P)-binding domain superfamily | Phosphopantetheine attachment site | Phosphopantetheine binding ACP domain | Polyketide and Nonribosomal Peptide Biosynthesis Enzymes | Polyketide synthase, beta-ketoacyl synthase domain | Polyketide synthase, C-terminal extension | Polyketide synthase, dehydratase domain, N-terminal | Polyketide synthase, dehydratase domain superfamily | Polyketide synthase-like, phosphopantetheine-binding domain | S-adenosyl-L-methionine-dependent methyltransferase superfamily | Thioesterase | Thiolase-like |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:E7F5V3 | InterPro | 2514 | |||||||||||||||||||||||
| UniProtKB:F8W3U6 | InterPro | ||||||||||||||||||||||||
| UniProtKB:A0A8M9Q0T1 | InterPro | 724 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-13L14 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-105J12 | ZFIN Curated Data | |
| Encodes | EST | fj34h12 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_009306806 (1) | 10039 nt | ||
| Genomic | GenBank:CU137725 (1) | 154486 nt | ||
| Polypeptide | UniProtKB:E7F5V3 (2) | 2514 aa |
- Chen, Y., Zheng, K., Leng, Y., Zhang, Z., Li, X., Li, X., Ou, H., Wen, M., Qiu, F., Yu, H. (2025) Alleviating effect of Lactobacillus fermentum E15 on hyperlipidemia and hepatic lipid metabolism in zebrafish fed by a high-fat diet through the production of short-chain fatty acids. Frontiers in nutrition. 12:15229821522982
- Chen, J., Zhao, W., Cao, L., Martins, R.S.T., Canário, A.V.M. (2024) Somatostatin signalling coordinates energy metabolism allocation to reproduction in zebrafish. BMC Biology. 22:163163
- Dharshan, S.S., Ramamurthy, K., Kaliraj, S., Manikandan, K., Chitra, V., Rajagopal, R., Alfarhan, A., Namasivayam, S.K.R., Kathiravan, M.K., Arockiaraj, J. (2024) Combined effects of vitamin D3 and dioxopiperidinamide derivative on lipid homeostasis, inflammatory pathways, and redox imbalance in non-alcoholic fatty liver disease in vivo zebrafish model. Biotechnology and applied biochemistry. :
- Donaka, R., Zheng, H., Ackert-Bicknell, C.L., Karasik, D. (2024) Early life lipid overload in Native American Myopathy is phenocopied by stac3 knockout in zebrafish. Gene. 936:149123
- Du, Q., Shao, R., Wang, W., Zhang, H., Liao, X., Wang, Z., Yin, Z., Ai, Q., Mai, K., Tang, X., Wan, M. (2024) Vitamin D3 Regulates Energy Homeostasis under Short-Term Fasting Condition in Zebrafish (Danio Rerio). Nutrients. 16(9):
- Gao, P., Chang, C., Liang, J., Du, F., Zhang, R. (2024) Embryonic Amoxicillin Exposure Has Limited Impact on Liver Development but Increases Susceptibility to NAFLD in Zebrafish Larvae. International Journal of Molecular Sciences. 25(5):
- Hsu, T.C., Chiang, C.H., Liu, I.H., Wang, C.Y., Chen, C.Y. (2024) Long-Term Yo-Yo Dieting Exaggerates Liver Steatosis and Lesions but Preserves Muscle Performance in Male Zebrafish. International Journal of Molecular Sciences. 25(23):
- Jia, J.Y., Chen, G.H., Shu, T.T., Lou, Q.Y., Jin, X., He, J.Y., Xiao, W.H., Zhai, G., Yin, Z. (2024) Androgen signaling inhibits de novo lipogenesis to alleviate lipid deposition in zebrafish. Zoological research. 45:355366355-366
- Jin, Y., Kozan, D., Young, E.D., Hensley, M., Shen, M.C., Wen, J., Moll, T., Anderson, J.L., Kozan, H., Rawls, J.F., Farber, S.A. (2024) A high-cholesterol zebrafish diet promotes hypercholesterolemia and fasting-associated liver steatosis. Journal of Lipid Research. 65(10):100637
- Li, Q., Pei, R., Chen, E., Zheng, F., Zhang, Y., Meng, S. (2024) Efficacy of Jiuzao polysaccharides in ameliorating alcoholic fatty liver disease and modulating gut microbiota. Heliyon. 10:e26167e26167
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