FIGURE

Fig. 6

ID

ZDB-FIG-200813-8

Publication

Lex et al., 2020 - Telomere shortening produces an inflammatory environment that increases tumor incidence in zebrafish

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Fig. 6

Increased tumor expansion in G2 tert−/− larvae is rescued by inflammation inhibition. (A) Allotransplants of primary tumor cells extracted from melanoma in adult fish into 2-dpf larvae that were treated with aspirin or Celecoxib (COX-2 selective inhibitor). (B) Representative images of melanoma expansion at 7 dpi upon aspirin treatment. (Scale bars: 0.5 mm.) (C) Time course of melanoma dissemination in WT and G2 tert−/− larvae under aspirin treatment. (D) Slope of HRAS melanoma spread among 1, 4, and 7 dpi. Comparison of tumor cell expansion in a WT or G2 tert−/− treated with aspirin (WT n = 26 and G2 tert−/− n = 29) or Celecoxib (WT n = 19 and G2 tert−/− n = 13). Each dot represents one larva allotransplant. ns, nonsignificant (P > 0.05).

Expression Data

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Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA