ZFIN Image: Lex et al., 2020, Fig. 6

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Figure Caption

Fig. 6 Increased tumor expansion in G2 tert−/− larvae is rescued by inflammation inhibition. (A) Allotransplants of primary tumor cells extracted from melanoma in adult fish into 2-dpf larvae that were treated with aspirin or Celecoxib (COX-2 selective inhibitor). (B) Representative images of melanoma expansion at 7 dpi upon aspirin treatment. (Scale bars: 0.5 mm.) (C) Time course of melanoma dissemination in WT and G2 tert−/− larvae under aspirin treatment. (D) Slope of HRAS melanoma spread among 1, 4, and 7 dpi. Comparison of tumor cell expansion in a WT or G2 tert−/− treated with aspirin (WT n = 26 and G2 tert−/− n = 29) or Celecoxib (WT n = 19 and G2 tert−/− n = 13). Each dot represents one larva allotransplant. ns, nonsignificant (P > 0.05).

Acknowledgments

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