ZFIN ID: ZDB-FIG-200622-31
Müller et al., 2020 - RNA exosome mutations in pontocerebellar hypoplasia alter ribosome biogenesis and p53 levels. Life science alliance   3(8) Full text @ Life Sci Alliance
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Observed In:
Stage: Day 5

Figure 7. <italic>exosc8</italic> and <italic>exosc9</italic> homozygous mutant zebrafish develop craniofacial abnormalities.

(A) Alcian blue staining in 5-dpf wild-type, exosc8 homozygous mutant, and exosc9 homozygous mutant zebrafish embryos. Scale bar: 500 μm. (B, C, D) Length of ceratohyal, (C) angle of ceratohyal, and (D) distance from Meckel’s cartilage to the ceratohyal in exosc8 homozygous mutant and exosc9 homozygous mutant zebrafish embryos. (B, C, D) 13 control, 18 exosc8 (c.26_27del), and 14 exosc9 (c.198_208del) homozygous larvae were measured for the quantification in (B, C, D). Error bars represent the standard error (±SEM), and statistical analysis was performed using unpaired t tests (exosc8 versus wt and exosc9 versus wt, respectively). The difference between mutant and wt is not significant where no P-value is given. Abbreviations: CH, ceratohyal; M, Meckel’s cartilage.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
exosc8cu201/cu201 standard conditions Day 5 ceratohyal bone decreased length, abnormal
Day 5 ceratohyal bone position, abnormal
Day 5 Meckel's cartilage distance ceratohyal bone, normal
exosc9cu202/cu202 standard conditions Day 5 ceratohyal bone decreased length, abnormal
Day 5 ceratohyal bone position, normal
Day 5 Meckel's cartilage decreased distance ceratohyal bone, abnormal
Acknowledgments:
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