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Fig 9
Loss of <italic>jag1b</italic> function decreases the penetrance of <italic>mef2ca</italic>-associated phenotypes.(A) Animals double heterozygous for mef2ca and jag1b were intercrossed, raised to 6 dpf and fixed and stained with Alcian Blue (cartilage) and Alizarin Red (bone). Genotyped animals were flat mounted and imaged. Removing functional copies of jag1b decreased mef2ca mutant penetrance. Scale bar: 50 μm. (B) Genotyped mef2ca;jag1b skeletal preparations were scored for penetrance of mef2ca-associated phenotypes. Asterisks indicate significance at alpha = 0.05 Fisher’s exact test compared with jag1b+/+. (C) Genotyped mef2ca;jag1b skeletal preparations were scored for penetrance of jag1b-associated phenotypes. Asterisks indicate significance at alpha = 0.05 Fisher’s exact test compared with mef2ca+/+.
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