ZFIN Figure: Sucharov et al., 2019, Fig 3

ZFIN ID: ZDB-FIG-191230-1544

ZFIN ID: ZDB-FIG-191230-1544

Sucharov et al., 2019 - Selective breeding modifies mef2ca mutant incomplete penetrance by tuning the opposing Notch pathway. PLoS Genetics 15:e1008507 Full text @ PLoS Genet.

ADDITIONAL FIGURES

PHENOTYPE:

Fish:	mef2ca^b1086/b1086
Observed In:	hyohyoideus interhyoideus intermandibularis
Stage:	Day 6

Fig 3 Selective breeding just for ectopic bone penetrance modifies penetrance of craniofacial muscle phenotypes.

6 dpf larvae were stained with Alizarin Red (magenta) and fluorescently labelled phalloidin (green) to mark bones and muscles, respectively. (A) The following craniofacial muscles are indicated in the micrograph and graphic: intermandibularis ant. (ima), intermandibularis post. (imp), interhyal (ih), hyohyal (hh), sternohyoideus (sh). Scale bar: 50 μm. (B) In the low-penetrance strain, mef2ca mutant muscles and bones resemble wild types. (C) In the high-penetrance strain, mef2ca mutants manifest muscle phenotypes (asterisks) in conjunction with ectopic bone phenotypes (arrowheads).

Gene Expression Details No data available

Antibody Labeling Details No data available

Phenotype Details

Fish	Conditions	Stage	Phenotype
mef2ca^b1086/b1086	standard conditions	Day 6	hyohyoideus inverted, abnormal
		Day 6	interhyoideus structure, abnormal
		Day 6	intermandibularis structure, abnormal

Acknowledgments:
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS Genet.