ZFIN ID: ZDB-FIG-191230-1544
Sucharov et al., 2019 - Selective breeding modifies mef2ca mutant incomplete penetrance by tuning the opposing Notch pathway. PLoS Genetics   15:e1008507 Full text @ PLoS Genet.
Observed In:
Stage: Day 6

Fig 3 Selective breeding just for ectopic bone penetrance modifies penetrance of craniofacial muscle phenotypes.

6 dpf larvae were stained with Alizarin Red (magenta) and fluorescently labelled phalloidin (green) to mark bones and muscles, respectively. (A) The following craniofacial muscles are indicated in the micrograph and graphic: intermandibularis ant. (ima), intermandibularis post. (imp), interhyal (ih), hyohyal (hh), sternohyoideus (sh). Scale bar: 50 μm. (B) In the low-penetrance strain, mef2ca mutant muscles and bones resemble wild types. (C) In the high-penetrance strain, mef2ca mutants manifest muscle phenotypes (asterisks) in conjunction with ectopic bone phenotypes (arrowheads).

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
mef2cab1086/b1086 standard conditions Day 6 hyohyoideus inverted, abnormal
Day 6 interhyoideus structure, abnormal
Day 6 intermandibularis structure, abnormal
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS Genet.