ZFIN ID: ZDB-FIG-190107-1
Blanco-Sánchez et al., 2018 - Grxcr1 Promotes Hair Bundle Development by Destabilizing the Physical Interaction between Harmonin and Sans Usher Syndrome Proteins. Cell Reports   25:1281-1291.e4 Full text @ Cell Rep.
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Observed In:
Stage: Day 5

Fig. 1

Grxcr1 Is Required for Stereocilium Widening in the Anterior Macula

(A–C) Phalloidin staining of the whole anterior macula in grxcr1+/+ (A), grxcr1b1259/b1259 (B), and grxcr1b1260/b1260 mutant larvae (C).

(D) Average number of hair bundles in grxcr1+/+ (n = 41 larvae), grxcr1b1259/b1259 (n = 35 larvae), and grxcr1b1260/b1260 mutant larvae (n = 32 larvae).

(E) Number of TUNEL-positive cells in grxcr1+/+ (n = 18 larvae) and grxcr1−/− mutant larvae (n = 28 larvae).

(F) Average hair bundle width at half their height in grxcr1+/+ (n = 40 larvae), grxcr1b1259/b1259 (n = 34 larvae), and grxcr1b1260/b1260 mutant larvae (n = 36 larvae).

Data are represented as mean ± SEM. p < 0.05, ∗∗p < 0.01; 5 dpf.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
grxcr1ab1259/b1259 standard conditions Day 5 hair cell anterior macula decreased width, abnormal
Day 5 hair cell anterior macula increased height, abnormal
Day 5 hair cell anterior macula morphology, abnormal
grxcr1ab1260/b1260 standard conditions Day 5 hair cell anterior macula decreased width, abnormal
Day 5 hair cell anterior macula increased height, abnormal
Day 5 hair cell anterior macula morphology, abnormal
Acknowledgments:
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Cell Rep.