FIGURE

Fig. S1

ID
ZDB-FIG-170123-7
Publication
Shih et al., 2016 - Exon- and contraction-dependent functions of titin in sarcomere assembly
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Fig. S1

Phenotypes of ttn.2 and ttn.1 mutants. A, Cardiac edema with decreased ventricle size (dashed circles) was noted in both ttn.2xu064 and ttn.2xu065, but not in ttn.1xu066 and ttn.1xu067. Shown are bright-field images at 2 dpf. Scale bar, 0.05 mm. B and C, In ttn.2xu064 and ttn.2xu065, the heart rate was slightly decreased (B), and the ventricular shortening fraction was reduced to zero (C). * and ** indicates p <0.05 and p <0.01, respectively . Means ±S.D. N=5. D, Bright-field images demonstrated that the cardiac edema was still present in both ttn.2xu064 and ttn.2xu065 at 3 dpf, but muscle disarray was more obvious in ttn.2xu065. Both ttn.2 mutants had whole-body edema at 7 dpf. ttn.1xu066 and ttn.1xu067 showed deflation of the swim bladder at 5 dpf (arrows). Scale bar, 1 mm. E, ttn.2xu064 and ttn.2xu065 mutants started to die at 7 dpf and could survive up to 10 dpf; ttn.1xu066 could survive until 12 dpf; and ttn.1xu067 started to die at 11 dpf and could live up to 17 dpf.

Expression Data

Expression Detail
Antibody Labeling
Phenotype Data
Fish:
Observed In:
Stage Range: Long-pec to Days 14-20

Phenotype Detail
Acknowledgments
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