FIGURE

Fig. 8

ID

ZDB-FIG-170123-6

Publication

Shih et al., 2016 - Exon- and contraction-dependent functions of titin in sarcomere assembly

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Fig. 8

Contraction-dependent myofibril damage to the slow muscle of ttn.2^xu064. (A) Slow muscle defects in ttn.2^xu064 embryos. Immunostaining for Myosin and Phalloidin staining to label Actin filaments in 2 dpf embryos. Arrows indicate the two rod-like structures enclosing the damaged myofibril region. (B) Fast muscle is intact in ttn.2^xu064. Immunostaining with antibodies against Tropomyosin and Myomesin or staining with Phalloidin in 2 dpf embryos. (C) ttn.2^xu064 mutants and siblings treated with 1% tricaine for 24 h or 0.07% bleach at 1 dpf for 5 min were fixed and immunostained for Myosin at 2 dpf. Scale bars: 5 μm.

Expression Data

Antibodies:	Ab1-myom Ab1-tpm
Fish:	WT ttn.2^xu064/xu064
Anatomical Term:	fast muscle cell
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ttn.2^xu064/xu064
Conditions:	chemical treatment by environment: bleaching agent chemical treatment by environment: tricaine
Observed In:	fast muscle cell myofibril slow muscle cell myofibril
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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