FIGURE

Fig. 1

ID

ZDB-FIG-131108-14

Publication

Choorapoikayil et al., 2013 - Loss of Pten promotes angiogenesis and enhanced vegfaa expression in zebrafish

Other Figures

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Fig. 1

Loss of Ptena and Ptenb leads to excessive filopodia formation in endothelial cells at 72 hpf. Endothelial cells in living wild-type (A) and ptena^-/-ptenb^-/- mutant (B) embryos were visualized using Tg(kdrl:eGFP) and confocal imaging was performed at 70–72 hpf. Intersegmental vessels along the trunk in ptena^-/-ptenb^-/- mutants (4/4) show excessive filopodia formation (arrowheads), whereas no filopodia were observed in wild-type (0/4) embryos. Anterior to the left, 40× + 1.5 zoom, 0.5 μm step size.

Expression Data

Gene:	EGFP
Fish:	s843Tg ptena^{hu1864/hu1864}; ptenb^{hu1435/hu1435}; s843Tg
Anatomical Terms:	endothelial cell intersegmental vessel
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ptena^{hu1864/hu1864}; ptenb^{hu1435/hu1435}; s843Tg
Observed In:	endothelial cell filopodium intersegmental vessel intersegmental vessel sprouting angiogenesis
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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