FIGURE

Fig. 3

ID

ZDB-FIG-121210-23

Publication

Shin et al., 2012 - Zebrafish neurofibromatosis type 1 genes have redundant functions in tumorigenesis and embryonic development

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Fig. 3

Increased proliferation drives OPC hyperplasia in nf1a^-/-; nf1b^-/- larvae. (A-H) Transverse spinal cord sections of wild-type3 Tg(olig2:GFP) (A-D) and nf1a^-/-; nf1b^-/-; Tg(olig2:GFP) larvae (E-H) labeled with anti-BrdU antibody (B,F, red) or anti-SOX10 antibody (C,G, magenta) at 4 dpf. Arrows indicate BrdU-negative, Tg(olig2:GFP)-, Sox10-positive OPCs. Arrowheads indicate BrdU-positive, Tg(olig2:GFP)-, Sox10-positive OPCs. (I,J) Quantification of total (I) and BrdU-positive OPCs (J) from transverse spinal cord sections of wild-type; Tg(olig2:GFP) and nf1a^-/-; nf1b^-/-; Tg(olig2:GFP) larvae at 4, 5 and 6 dpf. Values indicate mean + s.e.m. per section (n=30 from five each of wild-type and nf1a^-/-; nf1b^-/- larvae). **P<0.01; ***P<0.001. Scale bars: 20 μm.

Expression Data

Genes:	EGFP sox10
Antibody:	Ab1-sox10
Fish:	vu12Tg nf1a^p301/p301; nf1b^p303/p303; vu12Tg
Anatomical Term:	spinal cord glioblast (sensu Vertebrata)
Stage:	Day 4

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	nf1a^p301/p301; nf1b^p303/p303; vu12Tg
Observed In:	glioblast (sensu Vertebrata) oligodendrocyte progenitor proliferation spinal cord spinal cord glioblast (sensu Vertebrata)
Stage Range:	Day 4 to Day 6

Phenotype Detail

Acknowledgments

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