ZFIN ID: ZDB-FIG-110712-77
Gregory-Evans et al., 2011 - Gene-specific differential response to anti-apoptotic therapies in zebrafish models of ocular coloboma. Molecular Vision   17:1473-1484
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Conditions:
Observed In:
Stage Range: Day 5 to Days 7-13

Fig. 7

Effect of caspase inhibition on survival and optic fissure closure. A: Mean survival of gup mutant embryos with no treatment or with either diferuloylmethane, zVAD-fmk or control inhibitor zFA-fmk. n=30 for each group, meanĀ±SEM (*p<0.001). B: Wildtype (wt) larval phenotype at 8 dpf. C: Phenotype of gup mutants treated with 5 μM diferuloylmethane. D: Phenotype of gup mutant embryos treated with 300 μM zVAD-fmk. E: Phenotype of gup mutants treated with 300 μM zFA-fmk. Arrows indicate the position of the coloboma. Size bar in left panels=200 μm; size bar in right panels=500 μm.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
lamb1am189/m189 control Day 5 whole organism decreased life span, abnormal
lamb1am189/m189 chemical treatment by environment: curcumin Days 7-13 whole organism life span, ameliorated
lamb1am189/m189 chemical treatment by environment: Z-Val-Ala-Asp(OMe)-CH2F Days 7-13 whole organism life span, ameliorated
Acknowledgments:
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