Representative morphology of gup mutants at 48 hpf following drug treatment. Left panel, enlarged image of wholemount eye, scale bar=200 μm. Right panel, whole embryo morphology, scale bar=500 μm. A: Wildtype control, complete closure of optic fissure. B: Untreated gup mutant, displaying large open optic fissure at ventral aspect of eye. C: gup mutant treated with 5 μM diferuloylmethane, displaying open optic fissure which is smaller in size compared to untreated mutants. D: gup mutant treated with 300 μM zVAD-fmk, displaying a smaller open optic fissure than untreated mutants. E: gup mutant treated with 300 μM zFA-fmk, displaying a large open optic fissure as in untreated mutants. Optic fissure closure defect delineated by black dotted line.