ZFIN ID: ZDB-FIG-110712-73
Gregory-Evans et al., 2011 - Gene-specific differential response to anti-apoptotic therapies in zebrafish models of ocular coloboma. Molecular Vision   17:1473-1484
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Conditions:
Observed In:
Stage: Long-pec

Fig. 2

Representative morphology of gup mutants at 48 hpf following drug treatment. Left panel, enlarged image of wholemount eye, scale bar=200 μm. Right panel, whole embryo morphology, scale bar=500 μm. A: Wildtype control, complete closure of optic fissure. B: Untreated gup mutant, displaying large open optic fissure at ventral aspect of eye. C: gup mutant treated with 5 μM diferuloylmethane, displaying open optic fissure which is smaller in size compared to untreated mutants. D: gup mutant treated with 300 μM zVAD-fmk, displaying a smaller open optic fissure than untreated mutants. E: gup mutant treated with 300 μM zFA-fmk, displaying a large open optic fissure as in untreated mutants. Optic fissure closure defect delineated by black dotted line.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
lamb1am189/m189 control Long-pec closure of optic fissure decreased process quality, abnormal
Long-pec optic fissure increased width, abnormal
lamb1am189/m189 chemical treatment by environment: curcumin Long-pec closure of optic fissure process quality, ameliorated
Long-pec optic fissure width, ameliorated
lamb1am189/m189 chemical treatment by environment: Z-Val-Ala-Asp(OMe)-CH2F Long-pec closure of optic fissure process quality, ameliorated
Long-pec optic fissure width, ameliorated
Acknowledgments:
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