FIGURE

Fig. 2

ID

ZDB-FIG-110712-73

Publication

Gregory-Evans et al., 2011 - Gene-specific differential response to anti-apoptotic therapies in zebrafish models of ocular coloboma

Other Figures

All Figure Page

Back to All Figure Page

Fig. 2

Representative morphology of gup mutants at 48 hpf following drug treatment. Left panel, enlarged image of wholemount eye, scale bar=200 μm. Right panel, whole embryo morphology, scale bar=500 μm. A: Wildtype control, complete closure of optic fissure. B: Untreated gup mutant, displaying large open optic fissure at ventral aspect of eye. C: gup mutant treated with 5 μM diferuloylmethane, displaying open optic fissure which is smaller in size compared to untreated mutants. D: gup mutant treated with 300 μM zVAD-fmk, displaying a smaller open optic fissure than untreated mutants. E: gup mutant treated with 300 μM zFA-fmk, displaying a large open optic fissure as in untreated mutants. Optic fissure closure defect delineated by black dotted line.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	lamb1a^m189/m189
Conditions:	chemical treatment by environment: curcumin chemical treatment by environment: Z-Val-Ala-Asp(OMe)-CH2F
Observed In:	closure of optic fissure optic fissure
Stage:	Long-pec

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.