FIGURE

Fig. 3

ID

ZDB-FIG-100427-27

Publication

Binot et al., 2010 - Nkx6.1 and nkx6.2 regulate alpha- and beta-cell formation in zebrafish by acting on pancreatic endocrine progenitor cells

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Fig. 3

nkx6.1 and nkx6.2 pancreatic expression at 24 hpf. A–P: Double fluorescent WISHs showing expression at 24 hpf of nkx6.1 and glucagon (gcg) (A), insulin (ins) (B), somatostatin (sst) (C), ghrelin (ghr) (D), neuroD (E), sox4b (F) or pdx1 (G), of nkx6.2 and glucagon (H), insulin (I), somatostatin (J), ghrelin (K), neuroD (L), sox4b (M) or isl1 (N) and of isl1 and sox4b (O) or all the pancreatic hormone genes (P). Z-plane confocal images. Scale: 20 μm. Q: Schematic representation of pancreatic organization at 24 hpf. All views are lateral with anterior part to the left. h: hypochord.

Expression Data

Genes:	gcga ghrl ins isl1a neurod1 nkx6.1 nkx6.2 pdx1 sox4b sst2 (all 10)
Fish:	AB
Anatomical Terms:	gut pancreatic bud pancreatic bud ventral side posterior pancreatic bud
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 340(2), Binot, A.C., Manfroid, I., Flasse, L., Winandy, M., Motte, P., Martial, J.A., Peers, B., and Voz, M.L., Nkx6.1 and nkx6.2 regulate alpha- and beta-cell formation in zebrafish by acting on pancreatic endocrine progenitor cells, 397-407, Copyright (2010) with permission from Elsevier. Full text @ Dev. Biol.