Gene

pdx1

ID

ZDB-GENE-990415-122

Name

pancreatic and duodenal homeobox 1

Symbol

pdx1 Nomenclature History

Previous Names

pdx-1 (1)
ipf1 (1)
pancreatic and duodenal homeobox gene 1
zgc:100874

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

Predicted to have DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in determination of left/right symmetry; endocrine pancreas development; and glucose homeostasis. Predicted to localize to nucleus. Used to study diabetes mellitus. Human ortholog(s) of this gene implicated in cerebral infarction; hyperglycemia; maturity-onset diabetes of the young type 4; pancreatic agenesis; and type 2 diabetes mellitus. Is expressed in several structures, including digestive system; endoderm; intestinal rod; liver primordium; and somite. Orthologous to human PDX1 (pancreatic and duodenal homeobox 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

111 figures from 76 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

eu283 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 53 figures from 16 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pdx1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
maturity-onset diabetes of the young type 4	Alliance	MODY, type IV	606392
pancreatic agenesis	Alliance	Pancreatic agenesis 1	260370
type 2 diabetes mellitus	Alliance	{Diabetes mellitus, type II, susceptibility to}	125853

Associated With pdx1 Via Experimental Models

Human Disease	Fish	Conditions	Citations
diabetic retinopathy	pdx1^sa280/sa280; y1Tg/+	standard conditions	Ali et al., 2020
diabetic retinopathy	pdx1^uh10/uh10; y1Tg	standard conditions	Wiggenhauser et al., 2020
diabetes mellitus	li1Tg + MO1-pdx1	standard conditions	Al-Dahmani et al., 2022
diabetes mellitus	pdx1^sa280/sa280	standard conditions	Kimmel et al., 2015
hyperglycemia	pdx1^sa280/sa280	standard conditions	(2)

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017970	Homeobox, conserved site
Domain	IPR001356	Homeobox domain
Domain	IPR020479	Homeobox domain, metazoa
Family	IPR017995	Homeobox protein, antennapedia type
Homologous_superfamily	IPR009057	Homeobox-like domain superfamily