Gene
nkx6.1
- ID
- ZDB-GENE-040718-178
- Name
- NK6 homeobox 1
- Symbol
- nkx6.1 Nomenclature History
- Previous Names
-
- zgc:92879
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to have DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cell fate commitment; enteroendocrine cell differentiation; and spinal cord motor neuron differentiation. Predicted to localize to nucleus. Is expressed in several structures, including DEL; endoderm; nervous system; neural tube; and pancreatic system. Orthologous to human NKX6-1 (NK6 homeobox 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 43 figures from 30 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR000047 | Helix-turn-helix motif |
| Conserved_site | IPR017970 | Homeobox, conserved site |
| Domain | IPR001356 | Homeobox domain |
| Domain | IPR020479 | Homeobox domain, metazoa |
| Family | IPR033630 | Homeobox protein NKX-6.1 |
| Homologous_superfamily | IPR009057 | Homeobox-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Helix-turn-helix motif | Homeobox, conserved site | Homeobox domain | Homeobox domain, metazoa | Homeobox-like domain superfamily | Homeobox protein NKX-6.1 |
|---|---|---|---|---|---|---|---|
|
UniProtKB:F1QUC3
|
312 | ||||||
|
UniProtKB:Q5VJF4
|
312 | ||||||
|
UniProtKB:Q6DGK5
|
312 |
| Type | Name | Length (nt) | Analysis |
|---|---|---|---|
| mRNA |
nkx6.1-201
(1)
|
2023 nt |
Interactions and Pathways
No data available
Plasmids
No data available