Gene
nkx6.1
- ID
- ZDB-GENE-040718-178
- Name
- NK6 homeobox 1
- Symbol
- nkx6.1 Nomenclature History
- Previous Names
-
- zgc:92879
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within cell fate commitment; endocrine pancreas development; and spinal cord motor neuron differentiation. Predicted to be active in nucleus. Is expressed in several structures, including DEL; endoderm; nervous system; neural tube; and pancreatic system. Orthologous to human NKX6-1 (NK6 homeobox 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 44 figures from 31 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR000047 | Helix-turn-helix motif |
| Conserved_site | IPR017970 | Homeobox, conserved site |
| Domain | IPR001356 | Homeodomain |
| Domain | IPR020479 | Homeodomain, metazoa |
| Family | IPR050394 | Homeobox NK-like transcription regulators |
| Homologous_superfamily | IPR009057 | Homedomain-like superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Helix-turn-helix motif | Homedomain-like superfamily | Homeobox, conserved site | Homeobox NK-like transcription regulators | Homeodomain | Homeodomain, metazoa |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6DGK5 | InterPro | 312 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
nkx6.1-201
(1)
|
Ensembl | 2,023 nt |
Interactions and Pathways
No data available
Plasmids
No data available