Gene
nkx6.1
- ID
- ZDB-GENE-040718-178
- Name
- NK6 homeobox 1
- Symbol
- nkx6.1 Nomenclature History
- Previous Names
-
- zgc:92879
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Is predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cell differentiation and regulation of transcription by RNA polymerase II. Acts upstream of or within cell fate commitment; enteroendocrine cell differentiation; and spinal cord motor neuron differentiation. Is expressed in several structures, including DEL; endoderm; nervous system; neural tube; and pancreatic system. Orthologous to human NKX6-1 (NK6 homeobox 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 42 figures from 29 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR000047 | Helix-turn-helix motif |
Conserved_site | IPR017970 | Homeobox, conserved site |
Domain | IPR001356 | Homeobox domain |
Domain | IPR020479 | Homeobox domain, metazoa |
Family | IPR033630 | Homeobox protein NKX-6.1 |
Homologous_superfamily | IPR009057 | Homeobox-like domain superfamily |
Domain Details Per Protein
Protein | Length | Helix-turn-helix motif | Homeobox, conserved site | Homeobox domain | Homeobox domain, metazoa | Homeobox-like domain superfamily | Homeobox protein NKX-6.1 |
---|---|---|---|---|---|---|---|
UniProtKB:Q6DGK5
|
312 | ||||||
UniProtKB:Q5VJF4
|
312 | ||||||
UniProtKB:F1QUC3
|
312 |
Type | Name | Length (nt) | Analysis |
---|---|---|---|
mRNA |
nkx6.1-201
(1)
|
2023 nt |
Interactions and Pathways
No data available
Plasmids
No data available