FIGURE

Fig. 3

ID
ZDB-FIG-050428-1
Publication
Berghmans et al., 2005 - tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors
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Fig. 3

tp53 mutant embryos lack up-regulation of key downstream target genes after γ irradiation. Genes involved in the tp53 regulatory (tp53, mdm2), cell-cycle checkpoint (p21), and apoptotic (bax) pathways were analyzed in homozygous, heterozygous, and wild-type embryos with (+) or without (-) γ irradiation at 24 hpf (16 Gray). Gene expression was assayed at 30 hpf by single-embryo RT-PCR. Results are representative of at least five experiments. β actin was used to control gene expression.

Expression Data
Genes:
Fish:
Condition:
Anatomical Term:
Stage: Prim-15

Expression Detail
Antibody Labeling
Phenotype Data

Phenotype Detail
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA
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