Gene

mdm2

ID

ZDB-GENE-990415-153

Name

MDM2 proto-oncogene

Symbol

mdm2 Nomenclature History

Previous Names

etID309863.4 (1)
sb:eu923
zgc:109834

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Description

Is predicted to enable p53 binding activity and ubiquitin protein ligase activity. Involved in apoptotic process and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including negative regulation of apoptotic process; pronephric glomerulus morphogenesis; and response to X-ray. Predicted to be located in cytoplasm. Is expressed in several structures, including blood; digestive system; mesoderm; peripheral olfactory organ; and yolk syncytial layer. Human ortholog(s) of this gene implicated in chronic myeloid leukemia; endocrine gland cancer (multiple); glioblastoma; ichthyosis; and sarcoma. Orthologous to human MDM2 (MDM2 proto-oncogene).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

68 figures from 50 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:109834 (11 images)
eu923 (3 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 12 figures from 6 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mdm2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		?Lessel-Kubisch syndrome	618681
		{Accelerated tumor formation, susceptibility to}	614401

Associated With mdm2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001841	Zinc finger, RING-type
Domain	IPR001876	Zinc finger, RanBP2-type
Domain	IPR003121	SWIB/MDM2 domain
Domain	IPR022023	U1 small nuclear ribonucleoprotein of 70kDa N-terminal
Domain	IPR044080	MDM2, modified RING finger, HC subclass
Family	IPR015459	Ubiquitin-protein ligase E3 MDM2
Family	IPR016495	p53 negative regulator Mdm2/Mdm4
Family	IPR028340	E3 ubiquitin-protein ligase Mdm2
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily	IPR036443	Zinc finger, RanBP2-type superfamily
Homologous_superfamily	IPR036885	SWIB/MDM2 domain superfamily

Domain Details Per Protein

Protein	Length	E3 ubiquitin-protein ligase Mdm2	MDM2, modified RING finger, HC subclass	p53 negative regulator Mdm2/Mdm4	SWIB/MDM2 domain	SWIB/MDM2 domain superfamily	U1 small nuclear ribonucleoprotein of 70kDa N-terminal	Ubiquitin-protein ligase E3 MDM2	Zinc finger, RanBP2-type	Zinc finger, RanBP2-type superfamily	Zinc finger, RING/FYVE/PHD-type	Zinc finger, RING-type
UniProtKB:B0R0S8 InterPro	475
UniProtKB:A0A2R8Q7A7 InterPro	147
UniProtKB:Q561Z0 InterPro	475
UniProtKB:A0A0R4ISQ1 InterPro	486
UniProtKB:Q4V9B1 InterPro	164
UniProtKB:O42354 InterPro PDB	445
UniProtKB:A0A2R8Q0X4 InterPro	95
UniProtKB:B0R0S9 InterPro	159
UniProtKB:F1QU48 InterPro	440
UniProtKB:A0A2R8RRT2 InterPro	470

Transcripts

Genome Browsers

UCSC

Ensembl

ZFIN

Type	Name	Length (nt)	Analysis
mRNA	mdm2-201 (1) Ensembl	1965 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	mdm2-206 (1) Ensembl	584 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	mdm2-002 (1) Ensembl	642 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	mdm2-003 (1) Ensembl	294 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	mdm2-004 (1) Ensembl	607 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	mdm2-006 (1) Ensembl	400 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-mdm2	polyclonal	mdm2	IgG	Rabbit	IHC	AnaSpec	4

Plasmids

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations