Gene
mdm2
- ID
- ZDB-GENE-990415-153
- Name
- MDM2 proto-oncogene
- Symbol
- mdm2 Nomenclature History
- Previous Names
-
- etID309863.4 (1)
- sb:eu923
- zgc:109834
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Is predicted to enable p53 binding activity and ubiquitin protein ligase activity. Involved in apoptotic process and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including negative regulation of apoptotic process; pronephric glomerulus morphogenesis; and response to X-ray. Predicted to be located in cytoplasm. Is expressed in several structures, including blood; digestive system; mesoderm; peripheral olfactory organ; and yolk syncytial layer. Human ortholog(s) of this gene implicated in chronic myeloid leukemia; endocrine gland cancer (multiple); glioblastoma; ichthyosis; and sarcoma. Orthologous to human MDM2 (MDM2 proto-oncogene).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 68 figures from 50 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:109834 (11 images)
- eu923 (3 images)
Wild Type Expression Summary
- All Phenotype Data
- 12 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR001841 | Zinc finger, RING-type |
Domain | IPR001876 | Zinc finger, RanBP2-type |
Domain | IPR003121 | SWIB/MDM2 domain |
Domain | IPR022023 | U1 small nuclear ribonucleoprotein of 70kDa N-terminal |
Domain | IPR044080 | MDM2, modified RING finger, HC subclass |
Family | IPR015459 | Ubiquitin-protein ligase E3 MDM2 |
Family | IPR016495 | p53 negative regulator Mdm2/Mdm4 |
Family | IPR028340 | E3 ubiquitin-protein ligase Mdm2 |
Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
Homologous_superfamily | IPR036443 | Zinc finger, RanBP2-type superfamily |
Homologous_superfamily | IPR036885 | SWIB/MDM2 domain superfamily |
Domain Details Per Protein
Protein | Length | E3 ubiquitin-protein ligase Mdm2 | MDM2, modified RING finger, HC subclass | p53 negative regulator Mdm2/Mdm4 | SWIB/MDM2 domain | SWIB/MDM2 domain superfamily | U1 small nuclear ribonucleoprotein of 70kDa N-terminal | Ubiquitin-protein ligase E3 MDM2 | Zinc finger, RanBP2-type | Zinc finger, RanBP2-type superfamily | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type |
---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:B0R0S8
|
475 | |||||||||||
UniProtKB:A0A2R8Q7A7
|
147 | |||||||||||
UniProtKB:Q561Z0
|
475 | |||||||||||
UniProtKB:A0A0R4ISQ1
|
486 | |||||||||||
UniProtKB:Q4V9B1
|
164 | |||||||||||
UniProtKB:O42354
|
445 | |||||||||||
UniProtKB:A0A2R8Q0X4
|
95 | |||||||||||
UniProtKB:B0R0S9
|
159 | |||||||||||
UniProtKB:F1QU48
|
440 | |||||||||||
UniProtKB:A0A2R8RRT2
|
470 |
Interactions and Pathways
No data available
Plasmids