Gene

mdm2

ID
ZDB-GENE-990415-153
Name
MDM2 proto-oncogene
Symbol
mdm2 Nomenclature History
Previous Names
  • etID309863.4 (1)
  • sb:eu923
  • zgc:109834
Type
protein_coding_gene
Location
Chr: 4 Mapping Details/Browsers
Description
Is predicted to enable p53 binding activity and ubiquitin protein ligase activity. Involved in apoptotic process and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including negative regulation of apoptotic process; pronephric glomerulus morphogenesis; and response to X-ray. Predicted to be located in cytoplasm. Is expressed in several structures, including blood; digestive system; mesoderm; peripheral olfactory organ; and yolk syncytial layer. Human ortholog(s) of this gene implicated in chronic myeloid leukemia; endocrine gland cancer (multiple); glioblastoma; ichthyosis; and sarcoma. Orthologous to human MDM2 (MDM2 proto-oncogene).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
68 figures from 50 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
12 figures from 6 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mdm2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
?Lessel-Kubisch syndrome 618681
{Accelerated tumor formation, susceptibility to} 614401
Associated With mdm2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001841 Zinc finger, RING-type
Domain IPR001876 Zinc finger, RanBP2-type
Domain IPR003121 SWIB/MDM2 domain
Domain IPR022023 U1 small nuclear ribonucleoprotein of 70kDa N-terminal
Domain IPR044080 MDM2, modified RING finger, HC subclass
Family IPR015459 Ubiquitin-protein ligase E3 MDM2
Family IPR016495 p53 negative regulator Mdm2/Mdm4
Family IPR028340 E3 ubiquitin-protein ligase Mdm2
Homologous_superfamily IPR013083 Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily IPR036443 Zinc finger, RanBP2-type superfamily
Homologous_superfamily IPR036885 SWIB/MDM2 domain superfamily
Domain Details Per Protein
Protein Length E3 ubiquitin-protein ligase Mdm2 MDM2, modified RING finger, HC subclass p53 negative regulator Mdm2/Mdm4 SWIB/MDM2 domain SWIB/MDM2 domain superfamily U1 small nuclear ribonucleoprotein of 70kDa N-terminal Ubiquitin-protein ligase E3 MDM2 Zinc finger, RanBP2-type Zinc finger, RanBP2-type superfamily Zinc finger, RING/FYVE/PHD-type Zinc finger, RING-type
UniProtKB:B0R0S8 475
UniProtKB:A0A2R8Q7A7 147
UniProtKB:Q561Z0 475
UniProtKB:A0A0R4ISQ1 486
UniProtKB:Q4V9B1 164
UniProtKB:O42354 445
UniProtKB:A0A2R8Q0X4 95
UniProtKB:B0R0S9 159
UniProtKB:F1QU48 440
UniProtKB:A0A2R8RRT2 470
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-mdm2 polyclonal IgG Rabbit
  • IHC
AnaSpec
4
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations