Gene
mdm2
- ID
- ZDB-GENE-990415-153
- Name
- MDM2 proto-oncogene
- Symbol
- mdm2 Nomenclature History
- Previous Names
-
- etID309863.4 (1)
- sb:eu923
- zgc:109834
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to have metal ion binding activity and transferase activity. Involved in several processes, including negative regulation of apoptotic process; negative regulation of cell cycle arrest; and pronephric glomerulus morphogenesis. Predicted to localize to cytoplasm; nucleolus; and nucleoplasm. Is expressed in several structures, including blood; intestine; mesoderm; peripheral olfactory organ; and yolk syncytial layer. Human ortholog(s) of this gene implicated in chronic myeloid leukemia; endocrine gland cancer (multiple); glioblastoma multiforme; ichthyosis; and sarcoma. Orthologous to human MDM2 (MDM2 proto-oncogene).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 69 figures from 51 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:109834 (11 images)
- eu923 (3 images)
Wild Type Expression Summary
- All Phenotype Data
- 12 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001841 | Zinc finger, RING-type |
| Domain | IPR001876 | Zinc finger, RanBP2-type |
| Domain | IPR003121 | SWIB/MDM2 domain |
| Domain | IPR022023 | U1 small nuclear ribonucleoprotein of 70kDa N-terminal |
| Domain | IPR044080 | MDM2, modified RING finger, HC subclass |
| Family | IPR015459 | Ubiquitin-protein ligase E3 MDM2 |
| Family | IPR016495 | p53 negative regulator Mdm2/Mdm4 |
| Family | IPR028340 | E3 ubiquitin-protein ligase Mdm2 |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
| Homologous_superfamily | IPR036443 | Zinc finger, RanBP2-type superfamily |
| Homologous_superfamily | IPR036885 | SWIB/MDM2 domain superfamily |
Domain Details Per Protein
| Protein | Length | E3 ubiquitin-protein ligase Mdm2 | MDM2, modified RING finger, HC subclass | p53 negative regulator Mdm2/Mdm4 | SWIB/MDM2 domain | SWIB/MDM2 domain superfamily | U1 small nuclear ribonucleoprotein of 70kDa N-terminal | Ubiquitin-protein ligase E3 MDM2 | Zinc finger, RanBP2-type | Zinc finger, RanBP2-type superfamily | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A2R8Q0X4
|
95 | |||||||||||
|
UniProtKB:O42354
|
445 | |||||||||||
|
UniProtKB:B0R0S8
|
475 | |||||||||||
|
UniProtKB:Q561Z0
|
475 | |||||||||||
|
UniProtKB:Q4V9B1
|
164 | |||||||||||
|
UniProtKB:A0A2R8RRT2
|
470 | |||||||||||
|
UniProtKB:F1QU48
|
440 | |||||||||||
|
UniProtKB:B0R0S9
|
159 | |||||||||||
|
UniProtKB:A0A2R8Q7A7
|
147 | |||||||||||
|
UniProtKB:A0A0R4ISQ1
|
486 |
Interactions and Pathways
No data available
Plasmids