Gene
pak2a
- ID
- ZDB-GENE-021011-2
- Name
- p21 protein (Cdc42/Rac)-activated kinase 2a
- Symbol
- pak2a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within blood vessel development. Predicted to be active in cytoplasm. Is expressed in several structures, including Kupffer's vesicle; axial mesoderm; axial vasculature; axis; and central nervous system. Human ortholog(s) of this gene implicated in ductal carcinoma in situ. Orthologous to human PAK2 (p21 (RAC1) activated kinase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 19 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:91798 (8 images)
- cb422 (22 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ?Knobloch syndrome 2 | 618458 |
1 - 1 of 1
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | CRIB domain | CRIB domain superfamily | p21-activated kinase 2, catalytic domain | p21 activated kinase binding domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site | Serine/threonine-protein kinase PAK 3-like |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6DG42 | InterPro | 517 | |||||||||
| UniProtKB:A0AB32U004 | InterPro | 509 |
1 - 2 of 2
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Kahsay, A., Rodriguez-Marquez, E., López-Pérez, A., Hörnblad, A., von Hofsten, J. (2022) Pax3 loss of function delays tumour progression in kRAS-induced zebrafish rhabdomyosarcoma models. Scientific Reports. 12:17149
- Thirugnanam, K., Prabhudesai, S., Van Why, E., Pan, A., Gupta, A., Foreman, K., Zennadi, R., Rarick, K.R., Nauli, S.M., Palecek, S.P., Ramchandran, R. (2022) Ciliogenesis mechanisms mediated by PAK2-ARL13B signaling in brain endothelial cells is responsible for vascular stability. Biochemical pharmacology. 202:115143
- Wang, Y., Zhang, K., Guo, J., Yang, S., Shi, X., Pan, J., Sun, Z., Zou, J., Li, Y., Li, Y., Fan, T., Song, W., Cheng, F., Zeng, C., Li, J., Zhang, T., Sun, Z.S. (2022) Loss-of-Function of p21-Activated Kinase 2 Links BMP Signaling to Neural Tube Patterning Defects. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 10(4):e2204018
- Li, E., Wang, Y., Li, Q., Li, L., Wei, L. (2021) Protective Effects of Sal B on Oxidative Stress-Induced Aging by Regulating the Keap1/Nrf2 Signaling Pathway in Zebrafish. Molecules. 26(17):
- Peng, X., Lai, K.S., She, P., Kang, J., Wang, T., Li, G., Zhou, Y., Sun, J., Jin, D., Xu, X., Liao, L., Liu, J., Lee, E., Poss, K.D., Zhong, T.P. (2020) Induction of Wnt signaling antagonists and p21-activated kinase enhances cardiomyocyte proliferation during zebrafish heart regeneration. Journal of molecular cell biology. 13(1):41-58
- Sharma, P., MacLean, A.L., Meinecke, L., Clouthier, D., Nie, Q., Schilling, T.F. (2018) Transcriptomics reveals complex kinetics of dorsal-ventral patterning gene expression in the mandibular arch. Genesis (New York, N.Y. : 2000). 57(1):e23275
- Yu, Y., Yi, Y., Li, Y., Peng, T., Lao, S., Zhang, J., Liang, S., Xiong, Y., Shao, S., Wu, N., Zhao, Y., Huang, H. (2018) Dispersible MoS2 micro-sheets induced a proinflammatory response and apoptosis in the gills and liver of adult zebrafish. RSC Advances. 8:17826-17836
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Jagadeeshan, S., Sagayaraj, R.V., Paneerselvan, N., Ghouse, S.S., Malathi, R. (2017) Toxicity and anti-angiogenicity evaluation of Pak1 inhibitor IPA-3 using zebrafish embryo model. Cell biology and toxicology. 33(1):41-56
- Choe, C.P., Crump, J.G. (2015) Eph-Pak2a signaling regulates branching of the pharyngeal endoderm by inhibiting late-stage epithelial dynamics. Development (Cambridge, England). 142(6):1089-94
1 - 10 of 28
Show