Gene

pak2b

ID
ZDB-GENE-030131-3759
Name
p21 protein (Cdc42/Rac)-activated kinase 2b
Symbol
pak2b Nomenclature History
Previous Names
  • wu:fc52b03
  • zgc:113857
Type
protein_coding_gene
Location
Chr: 22 Mapping Details/Browsers
Description
Predicted to have protein serine/threonine kinase activity. Involved in blood vessel development. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in ductal carcinoma in situ. Is expressed in axial vasculature; endoderm; and nervous system. Orthologous to human PAK2 (p21 (RAC1) activated kinase 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pak2b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
?Knobloch syndrome 2 618458
Associated With pak2b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000095 CRIB domain
Domain IPR000719 Protein kinase domain
Domain IPR033923 p21 activated kinase binding domain
Domain IPR035064 p21-activated kinase 2, catalytic domain
Family IPR035065 Serine/threonine-protein kinase PAK2
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR036936 CRIB domain superfamily
Domain Details Per Protein
Protein Length CRIB domain CRIB domain superfamily p21-activated kinase 2, catalytic domain p21 activated kinase binding domain Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site Serine/threonine-protein kinase PAK2
UniProtKB:A5WVS3 253
UniProtKB:Q4V9B9 539
UniProtKB:Q502N8 263
UniProtKB:A5WVS2 537
UniProtKB:Q66IB7 248
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-pak Rabbit
  • IHC
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations