Publication	Data		Fish	Anatomy
Germano et al., 2022	Fig. 4		tbx16b104/b104	blood island mllt3 expression absent, abnormal
Osborn et al., 2020	Fig. 4		WT + MO3-tbx16	axial chorda mesoderm fgf8a expression decreased distribution, abnormal margin fgf8a expression increased distribution, abnormal notochord posterior-most region fgf3 expression increased distribution, abnormal notochord posterior-most region fgf4 expression increased distribution, abnormal notochord posterior-most region fgf8a expression increased distribution, abnormal presumptive paraxial mesoderm myf5 expression decreased distribution, abnormal presumptive paraxial mesoderm myod1 expression absent, abnormal segmental plate adaxial cell myf5 expression decreased distribution, abnormal segmental plate adaxial cell myod1 expression decreased distribution, abnormal somite adaxial cell myf5 expression decreased distribution, abnormal tail bud myf5 expression decreased distribution, abnormal
Hwang et al., 2018	Fig. S6		tbx16b104/b104 (AB)	pericardium edematous, abnormal
Goto et al., 2017	Fig. 1		tbx16b104/b104	tail bud vimr1 expression increased distribution, abnormal tail bud vimr2 expression increased distribution, abnormal
Morrow et al., 2017	Fig. 3		tbx16b104/b104	paraxial mesoderm msgn1 expression decreased amount, abnormal trunk somite absent, abnormal
	Fig. 4		tbx16b104/b104	angioblastic mesenchymal cell lmo2 expression spatial pattern, abnormal pronephros pax2a expression increased amount, abnormal spinal cord neuron pax2a expression increased amount, abnormal spinal cord neuron disorganized, abnormal vasculature fli1 expression spatial pattern, abnormal
	Fig. 5		tbx16b104/b104	hypochord sox2 expression spatial pattern, abnormal intermediate mesoderm sox2 expression spatial pattern, abnormal spinal cord motor neuron isl1a expression increased amount, abnormal tail bud isl1a expression increased distribution, abnormal
Nelson et al., 2017	Fig. 4		AB + MO3-tbx16 ,   ha01Tg + MO3-tbx16	endoderm sox17 expression decreased amount, abnormal endoderm EGFP expression decreased amount, abnormal endodermal cell decreased amount, abnormal presumptive endoderm sox32 expression decreased amount, abnormal whole organism mixl1 expression decreased amount, abnormal whole organism sox32 expression decreased amount, abnormal
	Fig. 5		AB + MO3-tbx16 ,   ha01Tg + MO3-tbx16	determination of digestive tract left/right asymmetry decreased occurrence, abnormal determination of liver left/right asymmetry decreased occurrence, abnormal determination of pancreatic left/right asymmetry decreased occurrence, abnormal digestive system foxa3 expression spatial pattern, abnormal digestive tract development process quality, abnormal endoderm EGFP expression spatial pattern, abnormal gut malformed, abnormal liver cp expression decreased amount, abnormal liver cp expression spatial pattern, abnormal liver development decreased occurrence, abnormal liver development process quality, abnormal liver position, abnormal pancreas ins expression decreased amount, abnormal pancreas ins expression spatial pattern, abnormal pancreas development decreased occurrence, abnormal pancreas development process quality, abnormal pancreas position, abnormal
Araya et al., 2014	Fig. 3		WT + MO1-tbx16 + MO2-tbx16	mesoderm decreased amount, abnormal
Arrington et al., 2013	Fig. 5		tbx16b104/b104	fibroblast growth factor receptor signaling pathway process quality, abnormal Kupffer's vesicle decreased size, abnormal Kupffer's vesicle development process quality, abnormal Kupffer's vesicle malformed, abnormal Kupffer's vesicle motile cilium decreased amount, abnormal Kupffer's vesicle motile cilium decreased length, abnormal Kupffer's vesicle physical object quality, abnormal
Huang et al., 2013	Fig. 6		tbx16b104/b104	convergent extension involved in nephron morphogenesis process quality, abnormal pronephric glomerulus morphogenesis process quality, abnormal
O'Neill et al., 2013	Fig. 1		tbx16b104/b104	tail bud increased size, abnormal trunk somite absent, abnormal
	Fig. 2		tbx16b104/b104	post-vent region somite decreased size, abnormal tail bud increased size, abnormal trunk somite decreased size, abnormal
	Fig. 3		tbx16b104/b104	tail bud increased size, abnormal
Warga et al., 2013	Fig. 1		tbx16b104/b104	blood cell decreased amount, abnormal leukocyte decreased amount, abnormal macrophage decreased amount, abnormal nucleate erythrocyte decreased amount, abnormal
	Fig. 2		tbx16b104/b104	blood cell decreased amount, abnormal endothelial cell decreased amount, abnormal pronephros cell increased amount, abnormal
Fior et al., 2012	Fig. 1		tbx16b104/b104	tail bud increased size, abnormal
Yabe et al., 2012	Fig. 1		tbx16kt378b/kt378b	somitogenesis disrupted, abnormal tail bud increased size, abnormal trunk somite absent, abnormal
Row et al., 2011	Fig. 2		WT + MO1-tbx16 + MO2-tbx16	hypoblast bleb increased amount, abnormal mesoderm morphology, abnormal mesodermal to mesenchymal transition involved in gastrulation disrupted, abnormal
	Fig. 3		WT + MO1-tbx16 + MO2-tbx16	mesodermal cell migration disrupted, abnormal mesodermal cell spatial pattern, abnormal
Wingert et al., 2011	Fig. 6		TU + MO4-tbx16	pronephric duct distal region increased length, abnormal pronephric duct proximal region decreased length, abnormal
Barresi et al., 2010	Fig. 6		tbx16hi3714Tg/hi3714Tg (AB/TU)	spinal cord radial glial cell morphology, abnormal
Mueller et al., 2010	Fig. 1		tbx16b104/b104	intermediate mesoderm calm1a expression decreased amount, abnormal intermediate mesoderm cebpa expression decreased amount, abnormal intermediate mesoderm drl expression decreased amount, abnormal intermediate mesoderm gb:bi430182 expression decreased amount, abnormal intermediate mesoderm gtpbp1 expression decreased amount, abnormal intermediate mesoderm hmbsa expression decreased amount, abnormal
	Fig. 2		tbx16b104/b104	paraxial mesoderm aldh1a2 expression decreased amount, abnormal paraxial mesoderm bmp3 expression decreased amount, abnormal paraxial mesoderm fgfrl1a expression decreased amount, abnormal paraxial mesoderm hsp90aa1.1 expression decreased amount, abnormal paraxial mesoderm rcan3 expression decreased amount, abnormal paraxial mesoderm unc45b expression decreased amount, abnormal
	Table 1		tbx16b104/b104	anterior lateral plate mesoderm cebpa expression decreased amount, abnormal immature eye aldh1a2 expression decreased amount, abnormal immature eye fgfrl1a expression decreased amount, abnormal intermediate mesoderm calm1a expression decreased amount, abnormal intermediate mesoderm cebpa expression decreased amount, abnormal intermediate mesoderm drl expression decreased amount, abnormal intermediate mesoderm gb:bi430182 expression decreased amount, abnormal intermediate mesoderm gtpbp1 expression decreased amount, abnormal intermediate mesoderm hmbsa expression decreased amount, abnormal neuroectoderm atp6v1e1b expression decreased amount, abnormal neuroectoderm bmp3 expression decreased amount, abnormal neuroectoderm calm1a expression decreased amount, abnormal neuroectoderm hebp2 expression decreased amount, abnormal neuroectoderm pinx1 expression decreased amount, abnormal neuroectoderm s1pr1 expression increased amount, abnormal neuroectoderm znf593 expression decreased amount, abnormal paraxial mesoderm aldh1a2 expression decreased amount, abnormal paraxial mesoderm bmp3 expression decreased amount, abnormal paraxial mesoderm exosc4 expression decreased amount, abnormal paraxial mesoderm fgfrl1a expression decreased amount, abnormal paraxial mesoderm hsp90aa1.1 expression decreased amount, abnormal paraxial mesoderm pinx1 expression decreased amount, abnormal paraxial mesoderm rcan3 expression decreased amount, abnormal paraxial mesoderm unc45b expression decreased amount, abnormal paraxial mesoderm znf593 expression decreased amount, abnormal polster atp6v1e1b expression decreased amount, abnormal polster pdap1b expression decreased amount, abnormal polster pinx1 expression decreased amount, abnormal tail bud hoxa11a expression increased amount, abnormal tail bud s1pr1 expression increased amount, abnormal whole organism atp5mea expression decreased amount, abnormal whole organism ciao2b expression decreased amount, abnormal whole organism cox14 expression increased amount, abnormal whole organism jak2a expression decreased amount, abnormal whole organism znhit1 expression decreased amount, abnormal
Burns et al., 2009	Fig. 1		tbx16hi3714Tg/hi3714Tg	hematopoietic stem cell differentiation disrupted, abnormal thymus primordium common lymphoid progenitor absent, abnormal ventral wall of dorsal aorta hematopoietic stem cell absent, abnormal
	Fig. 2		tbx16hi3714Tg/hi3714Tg	angiogenesis disrupted, abnormal artery morphogenesis disrupted, abnormal dorsal aorta morphology, abnormal intersegmental vessel aplastic, abnormal vasculogenesis disrupted, abnormal
	Fig. 3		tbx16hi3714Tg/hi3714Tg	angiogenesis disrupted, abnormal artery morphogenesis disrupted, abnormal dorsal aorta morphology, abnormal hematopoietic stem cell differentiation disrupted, abnormal intersegmental vessel aplastic, abnormal vasculogenesis disrupted, abnormal ventral wall of dorsal aorta hematopoietic stem cell absent, abnormal
Parkin et al., 2009	Fig. 8		tbx16unspecified/unspecified	pronephros aplastic, abnormal pronephros malformed, abnormal
Amack et al., 2007	Fig. 2		tbx16b104/b104 (AB)	Kupffer's vesicle decreased size, abnormal Kupffer's vesicle malformed, abnormal
	Fig. 3		tbx16b104/b104 (AB)	determination of left/right symmetry disrupted, abnormal
	Fig. 5		AB + MO3-tbx16	determination of left/right symmetry disrupted, abnormal diencephalon mislocalised, abnormal heart rudiment mislocalised, abnormal Kupffer's vesicle decreased size, abnormal Kupffer's vesicle malformed, abnormal notochord kinked, abnormal post-vent region shape, abnormal trunk morphology, abnormal
	Fig. 7		AB + MO3-tbx16	Kupffer's vesicle decreased size, abnormal Kupffer's vesicle malformed, abnormal
	Fig. 8		AB + MO3-tbx16 ,   tbx16b104/b104 (AB)	post-vent region shape, abnormal trunk morphology, abnormal
Muyskens et al., 2007	Fig. 4		tbx16b104/b104 (AB)	eye mislocalised, abnormal
Warga et al., 2007	Fig. 7		tbx16b104/b104	neural plate increased width, abnormal paraxial mesoderm disorganized, abnormal
Phenotype Annotation (1994-2006)	Fig. for (b104)		tbx16b104/b104 (AB)	fin decreased size, abnormal pectoral fin quality, abnormal post-vent region curved, abnormal somite size, abnormal surface structure quality, abnormal whole organism lethal (sensu genetics), abnormal whole organism shape, abnormal
	Fig. for (hi2109)		tbx16hi2109Tg	gut quality, abnormal heart quality, abnormal liver quality, abnormal notochord quality, abnormal somite quality, abnormal
	Fig. for (hi3714)		tbx16hi3714Tg	gut quality, abnormal heart quality, abnormal liver quality, abnormal notochord quality, abnormal somite quality, abnormal
	Fig. for (m423)		tbx16m423/m423 (AB)	pectoral fin quality, abnormal post-vent region quality, abnormal surface structure quality, abnormal whole organism shape, abnormal
	Fig. for (tm41)		tbx16tm41/tm41	gastrulation with mouth forming second quality, abnormal whole organism lethal (sensu genetics), abnormal
	Fig. for (tq5)		tbx16tq5/tq5	gastrulation with mouth forming second quality, abnormal whole organism lethal (sensu genetics), abnormal
Amsterdam et al., 2004	text only		tbx16hi2109Tg/hi2109Tg	gut hypoplastic, abnormal head anterior-posterior axis decreased length, abnormal head dorsal-ventral axis increased height, abnormal head swollen, abnormal liver hypoplastic, abnormal notochord morphology, abnormal pericardium edematous, abnormal somite border morphology, abnormal somite morphology, abnormal trunk anterior region decreased thickness, abnormal trunk anterior region kinked, abnormal trunk posterior region bulbous, abnormal trunk posterior region increased width, abnormal yolk condensed, abnormal yolk teardrop-shaped, abnormal
Amacher et al., 2002	Fig. 2		tbx16b104/b104	post-vent region spade-shaped, abnormal whole organism posterior region has fewer parts of type muscle, abnormal
	Fig. 3		tbx16b104/b104	mesoderm development process quality, abnormal
	Fig. 5		tbx16b104/b104	medial floor plate increased width, abnormal
	Fig. 6		tbx16b104/b104	medial floor plate cell mislocalised, abnormal medial floor plate increased width, abnormal
Biemar et al., 2001	Fig. 6		tbx16b104/b104 (AB)	pancreas development decreased process quality, abnormal pancreatic bud split medially, abnormal
Lekven et al., 2001	Fig. 7		tbx16b104/b104 (AB)	trunk somite aplastic, abnormal
Dheen et al., 1999	Fig. 6		tbx16b104/b104	notochord increased width, abnormal
Oates et al., 1999	Fig. 7		tbx16b104/b104	intermediate cell mass of mesoderm jak2a expression absent, abnormal lateral plate mesoderm jak2a expression absent, abnormal
	Table 1		tbx16b104/b104	hematopoietic system jak2a expression absent, abnormal
Weidinger et al., 1999	Fig. 7		tbx16b104/b104 (AB)	primordial germ cell mislocalised, abnormal
	Fig. 8		tbx16b104/b104 (AB)	primordial germ cell mislocalised, abnormal
Griffin et al., 1998	Fig. 2		tbx16b104/b104 (AB)	cell accumulation caudal fin, abnormal trunk lacks all parts of type somite, abnormal trunk muscle disorganized, abnormal trunk muscle malformed, abnormal
Hammerschmidt et al., 1996	Fig. 3		tbx16b104/b104 (AB)	post-anal tail morphogenesis disrupted, abnormal post-vent region increased size, abnormal post-vent region shape, abnormal somite aplastic, abnormal somitogenesis arrested, abnormal
	Fig. 4		tbx16b104/b104 (AB)	dorsal convergence disrupted, abnormal paraxial mesoderm morphology, abnormal presumptive paraxial mesoderm morphology, abnormal somite aplastic, abnormal tail bud increased size, abnormal
	text only		tbx16tq5/tq5 ,   tbx16tm41/tm41	dorsal convergence disrupted, abnormal somite aplastic, abnormal tail bud increased size, abnormal whole organism viability, abnormal
Solnica-Krezel et al., 1996	Fig. T1		tbx16m423/m423 (AB)	heart primordium left side unfused from heart primordium right side, abnormal pectoral fin aplastic, abnormal ventral fin fold cell mislocalised, abnormal
van Eeden et al., 1996	Table 1		tbx16tq5/tq5 ,   tbx16tm41/tm41	paraxial mesoderm morphology, abnormal whole organism viability, abnormal whole organism wholly dorsalized, abnormal