Publication	Data		Fish	Anatomy
Hisano et al., 2015	Fig. 3		spns2ko157/ko157	heart duplicated, abnormal heart morphogenesis process quality, abnormal heart shape, abnormal heart split bilaterally, abnormal
	Fig. 6		spns2ko157/ko157	heart duplicated, abnormal heart morphogenesis process quality, abnormal heart shape, abnormal heart split bilaterally, abnormal
	Fig. 9		spns2ko157/ko157	median fin blistered, abnormal
Nakanaga et al., 2014	Fig. 3		AB/TU + MO2-spns2	embryonic heart tube morphogenesis disrupted, abnormal
Hisano et al., 2013	Fig. 1		spns2ko157/ko157 ,   spns2ko157/+; ko07Tg	cardioblast migration to the midline involved in heart rudiment formation decreased process quality, abnormal cardioblast migration to the midline involved in heart rudiment formation disrupted, abnormal heart mislocalised laterally, abnormal heart tube increased amount, abnormal heart tube mislocalised laterally, abnormal
	Fig. 2		spns2ko157/ko157	ceratohyal cartilage decreased length, abnormal Meckel's cartilage decreased length, abnormal palatoquadrate cartilage decreased length, abnormal pharyngeal arch 1 embryonic morphogenesis disrupted, abnormal pharyngeal arch 1 morphology, abnormal
	Fig. 4		spns2ko157/ko157	pharyngeal arch 1 morphology, abnormal
Balczerski et al., 2012	Fig. 1		spns2b1110/b1110	ethmoid cartilage hypoplastic, abnormal mandibular arch skeleton hypoplastic, abnormal mandibular arch skeleton mislocalised, abnormal Meckel's cartilage aplastic, abnormal Meckel's cartilage disorganized, abnormal Meckel's cartilage hypoplastic, abnormal Meckel's cartilage malformed, abnormal neurocranial trabecula hypoplastic, abnormal palatoquadrate cartilage aplastic, abnormal
	Fig. 3		spns2b1110/b1110	oral ectoderm disorganized, abnormal oral ectoderm hypoplastic, abnormal oral ectoderm mislocalised anteriorly, abnormal pharyngeal ectoderm disorganized, abnormal pharyngeal ectoderm increased area, abnormal pharyngeal endoderm disorganized, abnormal pharyngeal endoderm mislocalised posteriorly, abnormal
	Fig. 5		spns2b1110/b1110	mandibular arch skeleton shape, abnormal mandibular arch skeleton size, abnormal
Kawahara et al., 2009	Fig. 1		spns2ko157/ko157	caudal fin blistered, abnormal heart bifurcated, abnormal heart edematous, abnormal
	Fig. 2		ko07Tg + MO2-spns2	heart bifurcated, abnormal
	Fig. 4		ko07Tg + MO2-spns2	heart bifurcated, abnormal
	Fig. S2		spns2ko157/ko157	heart bifurcated, abnormal
	Fig. S6		spns2ko157/ko157	caudal fin blistered, abnormal heart bifurcated, abnormal heart edematous, abnormal
Osborne et al., 2008	Fig. 1		ne2067Tg + MO1-spns2 ,   spns2sk12/sk12	blood circulation disrupted, abnormal caudal fin endoderm blistered, abnormal endoderm shape, abnormal endoderm structure, abnormal heart edematous, abnormal heart rudiment bifurcated, abnormal
	Fig. 2		WT + MO1-spns2	caudal fin endoderm blistered, abnormal heart edematous, abnormal
	Fig. 3		WT + MO1-spns2	heart bifurcated, abnormal