Publication	Data		Fish	Anatomy
Esser et al., 2018	Fig. 1		y1Tg + MO1-hey2	caudal artery efnb2a expression decreased amount, abnormal caudal artery efnb2a expression decreased distribution, abnormal
	Fig. 2		y1Tg + MO1-hey2	caudal artery ephb4a expression increased distribution, abnormal caudal vein plexus ephb4a expression increased amount, abnormal caudal vein plexus ephb4a expression increased distribution, abnormal
Gibb et al., 2018	Fig. 1		hey2hsc25/hsc25; sd2Tg ,   hey2hsc25/hsc25 ,   hey2hsc25/hsc25; twu34Tg	atrium cardiac muscle cell condensed, abnormal atrium increased size, abnormal blood cell accumulation trunk vasculature, abnormal cardiac ventricle cardiac muscle cell condensed, abnormal cardiac ventricle decreased size, abnormal heart contraction decreased rate, abnormal heart looping decreased occurrence, abnormal pericardium edematous, abnormal whole organism myh6 expression increased amount, abnormal whole organism myl7 expression increased amount, abnormal
	Fig. 2		hey2hsc25/hsc25; hsc4Tg ,   hey2hsc25/hsc25	atrium cardiac muscle cell increased amount, abnormal cardiac muscle cell increased amount, abnormal cardiac ventricle cardiac muscle cell increased amount, abnormal primitive heart tube myl7 expression increased distribution, abnormal primitive heart tube shape, abnormal whole organism myl7 expression increased amount, abnormal
	Fig. 3		hey2hsc25/hsc25	bulbus arteriosus cardiac muscle cell increased amount, abnormal bulbus arteriosus elongated, abnormal
	Fig. 6		hey2hsc25/hsc25	anterior lateral plate mesoderm hey2 expression increased amount, abnormal anterior lateral plate mesoderm hey2 expression increased distribution, abnormal anterior lateral plate mesoderm mef2cb expression increased amount, abnormal anterior lateral plate mesoderm mef2cb expression increased distribution, abnormal anterior lateral plate mesoderm nkx2.5 expression increased amount, abnormal anterior lateral plate mesoderm nkx2.5 expression increased distribution, abnormal heart tube ltbp3 expression increased amount, abnormal heart tube ltbp3 expression increased distribution, abnormal heart tube mef2cb expression increased amount, abnormal heart tube mef2cb expression increased distribution, abnormal heart tube nkx2.5 expression increased amount, abnormal heart tube nkx2.5 expression increased distribution, abnormal whole organism hey2 expression increased amount, abnormal whole organism ltbp3 expression increased amount, abnormal whole organism mef2cb expression increased amount, abnormal whole organism nkx2.5 expression increased amount, abnormal
	Fig. 7		hey2hsc25/hsc25; fb7Tg ,   AB/TL + MO2-hey2 ,   fb7Tg + MO2-hey2	atrium cell population proliferation increased occurrence, abnormal bulbus arteriosus cell population proliferation increased occurrence, abnormal cardiac muscle cell cell population proliferation increased occurrence, abnormal cardiac ventricle cell population proliferation increased occurrence, abnormal pharyngeal mesoderm hey2 expression increased amount, abnormal pharyngeal mesoderm hey2 expression increased distribution, abnormal pharyngeal mesoderm tbx1 expression increased amount, abnormal pharyngeal mesoderm tbx1 expression increased distribution, abnormal
Chen et al., 2017	Fig. 3		s843Tg; uto5Tg + MO1-hey2	dorsal aorta anatomical region mCherry expression absent, abnormal dorsal aorta vascular associated smooth muscle cell decreased amount, abnormal dorsal aorta vascular associated smooth muscle cell mCherry expression absent, abnormal
Chou et al., 2010	Fig. 3		WT + MO1-hey2	artery absent, abnormal blood circulation absent, abnormal dorsal aorta absent, abnormal interrenal primordium centered, abnormal intersegmental vessel absent, abnormal posterior cardinal vein morphology, abnormal pronephric glomerular capillary absent, abnormal vein morphology, abnormal
Herbert et al., 2009	Fig. 2		WT + MO1-hey2	blood vessel morphogenesis disrupted, abnormal dorsal aorta aplastic, abnormal
Gray et al., 2007	Fig. 1		hey2m145/m145; y1Tg	blood circulation disrupted, abnormal dorsal aorta closed, abnormal dorsal aorta collapsed, abnormal intersegmental vessel collapsed, abnormal subintestinal vein collapsed, abnormal
Jia et al., 2007	Fig. 1		hey2m145/m145	heart sarcomere increased size, abnormal
	Fig. 2		hey2m145/m145; f1Tg/+ ,   hey2vu59/vu59 ,   hey2m145/m145	atrial myocardium cardiac muscle cell decreased mass density, abnormal atrial myocardium cardiac muscle cell increased amount, abnormal atrium increased size, abnormal cardiac ventricle decreased size, abnormal heart cardiac muscle cell increased size, abnormal heart increased size, abnormal heart looping disrupted, abnormal mitotic cell cycle duration, abnormal ventricular myocardium cardiac muscle cell increased amount, abnormal ventricular myocardium cardiac muscle cell increased mass density, abnormal
	Fig. 5		hey2m145/m145	heart increased size, abnormal
Phenotype Annotation (1994-2006)	Fig. for (m145)		hey2m145/m145 (AB)	anatomical system quality, abnormal heart quality, abnormal
Zhong et al., 2000	Fig. 3		hey2m145/m145 (AB)	blood circulation arrested, abnormal dorsal aorta closed, abnormal
Stainier et al., 1996	Table 1		hey2m145/m145 (AB)	blood circulation disrupted, abnormal brain hemorrhagic, abnormal cranial vasculature broken, abnormal