PUBLICATION

Kremen1 regulates the regenerative capacity of support cells and mechanosensory hair cells in the zebrafish lateral line

Authors
Megerson, E., Kuehn, M., Leifer, B., Bell, J.M., Snyder, J.L., McGraw, H.F.
ID
ZDB-PUB-240111-25
Date
2023
Source
iScience   27: 108678108678 (Journal)
Registered Authors
Snyder, Julia
Keywords
Cell biology, Molecular biology, Physiology
MeSH Terms
none
PubMed
38205258 Full text @ iScience
Abstract
Mechanosensory hair cells in the inner ear mediate the sensations of hearing and balance, and in the specialized lateral line sensory system of aquatic vertebrates, the sensation of water movement. In mammals, hair cells lack the ability to regenerate following damage, resulting in sensory deficits. In contrast, non-mammalian vertebrates, such as zebrafish, can renew hair cells throughout their lifespan. Wnt signaling is required for development of inner ear and lateral line hair cells and regulates regeneration. Kremen1 inhibits Wnt signaling and hair cell formation, though its role in regeneration is unknown. We used a zebrafish kremen1 mutant line to show overactive Wnt signaling results in supernumerary support cells and hair cell regeneration without increased proliferation, in contrast with the previously described role of Wnt signaling during hair cell regeneration. This work allows us to understand the biology of mechanosensory hair cells and how regeneration might be promoted following damage.
Genes / Markers
Figures
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Expression
Phenotype
No data available
Mutations / Transgenics
Allele Construct Type Affected Genomic Region
nl10
    Point Mutation
    w186TgTransgenic Insertion
      w215TgTransgenic Insertion
      w217TgTransgenic Insertion
      w218TgTransgenic Insertion
      1 - 5 of 5
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      Human Disease / Model
      No data available
      Sequence Targeting Reagents
      No data available
      Fish
      No data available
      Antibodies
      Name Type Antigen Genes Isotypes Host Organism
      Ab1-otofmonoclonalIgG2aMouse
      Ab18-sox2polyclonal
        IgGRabbit
        1 - 2 of 2
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        Orthology
        No data available
        Engineered Foreign Genes
        Marker Marker Type Name
        EGFPEFGEGFP
        EosEFGEos
        1 - 2 of 2
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        Mapping
        No data available